Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

被引：8
|
作者：
Nemeth, Andras Gy. [1 ]
Szabo, Renata [1 ]
Orsy, Gyorgy [2 ]
Mandity, Istvan M. [2 ]
Keseru, Gyorgy M. [1 ]
Abranyi-Balogh, Peter [1 ]
机构：
[1] Res Ctr Nat Sci, Med Chem Res Grp, H-1117 Budapest, Hungary
[2] Res Ctr Nat Sci, Lendulet Artificial Transporters Res Grp, H-1117 Budapest, Hungary
来源：
MOLECULES | 2021年 / 26卷 / 02期
关键词：
continuous flow; sulfur; aqueous polysulfide solution; thiourea; multicomponent reaction;
D O I：
10.3390/molecules26020303
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.
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页数：9
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