Stem cells - A new route to rejuvenation

被引:11
作者
Surani, M. Azim [1 ]
McLaren, Anne [1 ]
机构
[1] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
关键词
D O I
10.1038/443284a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Embryonic stem cells are prized for their ability to mature into all the specialized adult cell types. It may now be possible to reprogramme adult body cells to have the characteristics of stem cells.
引用
收藏
页码:284 / 285
页数:2
相关论文
共 10 条
[1]   Chromatin signatures of pluripotent cell lines [J].
Azuara, V ;
Perry, P ;
Sauer, S ;
Spivakov, M ;
Jorgensen, HF ;
John, RM ;
Gouti, M ;
Casanova, M ;
Warnes, G ;
Merkenschlager, M ;
Fisher, AG .
NATURE CELL BIOLOGY, 2006, 8 (05) :532-U189
[2]   A bivalent chromatin structure marks key developmental genes in embryonic stem cells [J].
Bernstein, BE ;
Mikkelsen, TS ;
Xie, XH ;
Kamal, M ;
Huebert, DJ ;
Cuff, J ;
Fry, B ;
Meissner, A ;
Wernig, M ;
Plath, K ;
Jaenisch, R ;
Wagschal, A ;
Feil, R ;
Schreiber, SL ;
Lander, ES .
CELL, 2006, 125 (02) :315-326
[3]   Core transcriptional regulatory circuitry in human embryonic stem cells [J].
Boyer, LA ;
Lee, TI ;
Cole, MF ;
Johnstone, SE ;
Levine, SS ;
Zucker, JR ;
Guenther, MG ;
Kumar, RM ;
Murray, HL ;
Jenner, RG ;
Gifford, DK ;
Melton, DA ;
Jaenisch, R ;
Young, RA .
CELL, 2005, 122 (06) :947-956
[4]   LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism [J].
Cartwright, P ;
McLean, C ;
Sheppard, A ;
Rivett, D ;
Jones, K ;
Dalton, S .
DEVELOPMENT, 2005, 132 (05) :885-896
[5]  
ILVANOVA N, 2006, NATURE, V442, P533
[6]   Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression [J].
Kuroda, T ;
Tada, M ;
Kubota, H ;
Kimura, H ;
Hatano, S ;
Suemori, H ;
Nakatsuji, N ;
Tada, T .
MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (06) :2475-2485
[7]   Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4 [J].
Li, Y ;
McClintick, J ;
Zhong, L ;
Edenberg, HJ ;
Yoder, MC ;
Chan, RJ .
BLOOD, 2005, 105 (02) :635-637
[8]  
Silva J, 2006, NATURE, V441, P997, DOI 10.1038/nature04914
[9]   Nuclear reprogramming by human embryonic stem cells [J].
Surani, MA .
CELL, 2005, 122 (05) :653-654
[10]   Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors [J].
Takahashi, Kazutoshi ;
Yamanaka, Shinya .
CELL, 2006, 126 (04) :663-676