Coronavirus Disease 2019-Associated Coagulopathy

被引：88

作者：

Lippi, Giuseppe ^{[1
]}

Sanchis-Gomar, Fabian ^{[2
,3
]}

Favaloro, Emmanuel J. ^{[4
,5
]}

Lavie, Carl J. ^{[6
]}

Henry, Brandon M. ^{[7
]}

机构：

[1] Univ Verona, Sect Clin Biochem, Verona, Italy

[2] Univ Valencia, Dept Physiol, Fac Med, Ave Blasco Ibanez 15, Valencia 46010, Spain

[3] INCLIVA Biomed Res Inst, Valencia, Spain

[4] Westmead Hosp, Inst Clin Pathol & Med Res ICPMR, NSW Hlth Pathol, Sydney Ctr Thrombosis,Haematol, Westmead, NSW, Australia

[5] Westmead Hosp, Inst Clin Pathol & Med Res ICPMR, NSW Hlth Pathol, Sydney Ctr Haemostasis,Haematol, Westmead, NSW, Australia

[6] Univ Queensland, John Ochsner Heart & Vasc Inst, Ochsner Clin Sch, Sch Med, New Orleans, LA USA

[7] Cincinnati Childrens Hosp Med Ctr, Cardiac Intens Care Unit, Heart Inst, Cincinnati, OH 45229 USA

来源：

MAYO CLINIC PROCEEDINGS | 2021年 / 96卷 / 01期

关键词：

ANTIPHOSPHOLIPID ANTIBODIES; ANGIOTENSIN; 1-7; TISSUE FACTOR; OBESITY; COVID-19; THROMBOSIS; ASSOCIATION; HEMOSTASIS; ABNORMALITIES; COAGULATION;

D O I：

10.1016/j.mayocp.2020.10.031

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently found to suffer from both arterial and venous thrombotic events due to the perpetuation of a hypercoagulable state. This phenomenon, termed COVID-19-associated coagulopathy, is now considered a major component of the pathophysiology of this novel infectious disease, leading to widespread thrombosis. While at first, the vascular insults may be limited to the pulmonary microvasculature, as the disease progresses, systemic involvement occurs, culminating in distant organ thrombosis and multiorgan dysfunction syndrome. In this review article, we discuss recent insights into the pathophysiologic mechanisms of COVID-19-associated coagulopathy and review the clinical, histopathologic, and laboratory evidence, which leads us to conclude that COVID-19 is both a pulmonary and vascular disorder. (C) 2020 Mayo Foundation for Medical Education and Research

引用

页码：203 / 217

页数：15

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