Nonlinear photoacoustic waves for light guiding to deep tissue sites

被引:5
|
作者
Ishijima, Ayumu [1 ]
Yagyu, Ukyo [2 ]
Kitamura, Kenta [3 ]
Tsukamoto, Akira [4 ]
Sakuma, Ichiro [1 ,2 ,3 ]
Nakagawa, Keiichi [2 ,3 ]
机构
[1] Univ Tokyo, Med Device Dev & Regulat Res Ctr, Tokyo 1138656, Japan
[2] Univ Tokyo, Dept Precis Engn, Tokyo 1138656, Japan
[3] Univ Tokyo, Dept Bioengn, Tokyo 1138656, Japan
[4] Natl Def Acad, Dept Appl Phys, Yokosuka, Kanagawa 2398686, Japan
基金
日本学术振兴会;
关键词
PHOTODYNAMIC THERAPY; TIME;
D O I
10.1364/OL.44.003006
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Light scattering by tissues limits performance in biological sensing or stimulation. Here we present a photoacoustic technique that increases light transmittance by one order of magnitude and enables light localization in deep tissue. Laser-induced nonlinear acoustic waves are utilized to produce a high refractive index contrast in scattering medium without high-intensity pressure. The size of guiding area is around 60 mu m, which is equivalent or smaller than the diameter of multimode fibers. To show potential use in biomedical fields, we performed light guiding and imaging of fluorescence, through swine tissues with thickness more than 1 mm. (C) 2019 Optical Society of America
引用
收藏
页码:3006 / 3009
页数:4
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