Thin-layer chromatography: A neglected technique

被引：18
|
作者：
Wilson, ID
机构：
来源：
THERAPEUTIC DRUG MONITORING | 1996年 / 18卷 / 04期
关键词：
thin-layer chromatography; high-performance thin-layer chromatography; quantitative analysis; identification;
D O I：
10.1097/00007691-199608000-00030
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Thin-layer(or planar) chromatography (TLC) is critically reviewed from the point of view of drug analysis in biological fluids. The capabilities of the various techniques of TLC are described and their advantages and disadvantages are discussed. An example of the use of high-performance TLC with scanning densitometry for the quantitative determination of antipyrine in human plasma is provided. The use of TLC-mass spectrometry and TLC-tandem mass spectrometry, directly from the sorbent, in the identification of the compounds separated by TLC is discussed.
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页码：484 / 492
页数：9
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