Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients

被引：260

作者：

Dai, Yong ^{[2
]}

Sui, Weiguo

Lan, Huijuan

Yan, Qiang

Huang, He

Huang, YuanShuai ^{[1
]}

机构：

[1] Chongqing Med Univ, Key Lab Lab Med Diagnost, Minist Educ, Chongqing 400016, Peoples R China

[2] Jinan Univ, Clin Med Coll 2, Shenzhen Peoples Hosp, Jinan 518020, Guangdong, Peoples R China

来源：

RHEUMATOLOGY INTERNATIONAL | 2009年 / 29卷 / 07期

关键词：

MicroRNA; Microarray; Lupus nephritis; Human; ERYTHEMATOSUS; CANCERS; RNA; BIOGENESIS; MECHANISM; ELEGANS; FAMILY;

D O I：

10.1007/s00296-008-0758-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) are noncoding RNA molecules of 21-24 nt that regulate the expression of target genes in a post-transcriptional manner. Evidence indicates that miRNAs play essential roles in embryogenesis, cell differentiation, and pathogenesis of human diseases. This study describes a comparison between the miRNA profile of kidney biopsies from lupus nephritis (LN) patients and the controls, to develop further understanding of the pathogenesis of LN. Kidney biopsies were taken from five LN patients detected LN Class II and three normal controls. The miRNA microarray chip analysis identified 66 miRNAs differentially expressed in LN. The chip results were confirmed by QRT-PCR. This work indicates that miRNAs are potential diagnosis biomarkers and probable factors involved in the pathogenesis of LN.

引用

页码：749 / 754

页数：6

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