Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities

被引：302

作者：

Calses, Philamer C. ^{[1
,2
]}

Crawford, James J. ^{[3
]}

Lill, Jennie R. ^{[2
]}

Dey, Anwesha ^{[1
]}

机构：

[1] Genentech Inc, Dept Discovery Oncol, 1 DNA Way, San Francisco, CA 94080 USA

[2] Genentech Inc, Dept Microchem Prote & Lipid, 1 DNA Way, San Francisco, CA 94080 USA

[3] Genentech Inc, Dept Discovery Chem, 1 DNA Way, San Francisco, CA 94080 USA

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 05期

关键词：

SQUAMOUS-CELL CARCINOMA; EFFECTOR YAP; ANTITUBULIN DRUGS; RESISTANCE; TEAD; ACTIVATION; YAP/TAZ; OVEREXPRESSION; SENSITIVITY; INHIBITION;

D O I：

10.1016/j.trecan.2019.04.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Hippo pathway remains a central focus in both basic and translational research and is a key modulator of developmental biology. Dysregulation of the pathway is associated with a plethora of human cancers and there are multiple efforts to target key components of the pathway for disease intervention. In this review, we briefly highlight the latest research advances around the core components of the Hippo pathway in cancer. More specifically, we discuss several genetic aberrations of these factors as mechanisms for the development of cancers, including genetic amplification, deletion, and gene fusions. Additionally, we highlight the role of the Hippo pathway in cancer therapy resistance and tumor immunogenicity. Last, we summarize the ongoing efforts to target the pathway in cancers.

引用

页码：297 / 307

页数：11

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