Speciation of copper in a range of food types by X-ray absorption spectroscopy

被引:28
作者
Ceko, Melanie J. [1 ]
Aitken, Jade B. [2 ]
Harris, Hugh H. [1 ]
机构
[1] Univ Adelaide, Sch Chem & Phys, Adelaide, SA 5005, Australia
[2] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
基金
澳大利亚研究理事会;
关键词
Dietary copper; X-ray absorption spectroscopy; Copper speciation; Chronic copper toxicity; RESPONSE RELATIONSHIPS; ALZHEIMERS-DISEASE; DRINKING-WATER; TOXICITY; BIOCHEMISTRY; METABOLISM; MECHANISMS; HEALTH; SITE; IRON;
D O I
10.1016/j.foodchem.2014.05.018
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Copper (Cu) is an essential element and the effects of diets deficient in it are well established. However, the effects of long-term high copper intake are less clear. The chemical form of copper from food sources and its resultant bioavailability is a potentially important factor in its biological activity. X-ray Absorption Near-Edge Structure (XANES) was used to determine the chemical forms of Cu in a range of foods that would make significant contributions to total copper absorption in a standard diet, as well as a chlorinated tap water sample. Analysis of the Cu K-edge XANES spectra suggested that Cu existed in both Cu(I) and Cu(II) forms, with the following five model compounds: Cu(I) acetate; Cu(II) acetate; Cu(I)-glutathione; Cu(I)-cysteine; and, Cu(II)-histidine being fitted to the sample spectra. This research suggested that the absorption of dietary copper could vary markedly dependent on the types of food consumed and the different bioavailability of the Cu species they contain. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:50 / 54
页数:5
相关论文
共 29 条
[21]   Trace amounts of copper in water induce b-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease [J].
Sparks, DL ;
Schreurs, BG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :11065-11069
[22]   Copper and human health: Biochemistry, genetics, and strategies for modeling dose-response relationships [J].
Stern, Bonnie Ransom ;
Solioz, Marc ;
Krewski, Daniel ;
Aggett, Peter ;
Aw, Tar-Ching ;
Baker, Scott ;
Crump, Kenny ;
Dourson, Michael ;
Haber, Lynne ;
Hertzberg, Rick ;
Keen, Carl ;
Meek, Bette ;
Rudenko, Larisa ;
Schoeny, Rita ;
Slob, Wout ;
Starr, Tom .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS, 2007, 10 (03) :157-222
[23]   Essentiality and Toxicity in Copper Health Risk Assessment: Overview, Update and Regulatory Considerations [J].
Stern, Bonnie Ransom .
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2010, 73 (2-3) :114-127
[24]   Trace elements in human physiology and pathology. Copper [J].
Tapiero, H ;
Townsend, DM ;
Tew, KD .
BIOMEDICINE & PHARMACOTHERAPY, 2003, 57 (09) :386-398
[25]   Human whole-body copper metabolism [J].
Turnlund, JR .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 67 (05) :960S-964S
[26]  
Turnlund JR, 2004, AM J CLIN NUTR, V79, P1037
[27]   Copper absorption and bioavailability [J].
Wapnir, RA .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 67 (05) :1054S-1060S
[28]  
World Health Organization, 1996, Trace Elements in Human Nutrition and Health
[29]   Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. Insights into mechanisms of copper uptake and hypoxia selectivity [J].
Xiao, Zhiguang ;
Donnelly, Paul S. ;
Zimmermann, Matthias ;
Wedd, Anthony G. .
INORGANIC CHEMISTRY, 2008, 47 (10) :4338-4347