High-dose proton beam therapy for sinonasal mucosal malignant melanoma

被引：44

作者：

Fuji, Hiroshi ^{[1
,7
]}

Yoshikawa, Shusuke ^{[2
]}

Kasami, Masako ^{[3
]}

Murayama, Shigeyuki ^{[1
]}

Onitsuka, Tetsuro ^{[4
,5
]}

Kashiwagi, Hiroya ^{[6
]}

Kiyohara, Yoshio ^{[2
]}

机构：

[1] Shizuoka Canc Ctr Hosp, Div Proton Therapy, Shizuoka 4118777, Japan

[2] Shizuoka Canc Ctr Hosp, Div Dermatol, Shizuoka 4118777, Japan

[3] Shizuoka Canc Ctr Hosp, Div Pathl, Shizuoka 4118777, Japan

[4] Shizuoka Canc Ctr Hosp, Div Head Surg, Shizuoka 4118777, Japan

[5] Shizuoka Canc Ctr Hosp, Div Neck Surg, Shizuoka 4118777, Japan

[6] Shizuoka Canc Ctr Hosp, Div Opthalomol, Shizuoka 4118777, Japan

[7] Natl Ctr Child Hlth & Dev, Div Radiat Oncol, Setagaya Ku, Tokyo 1578535, Japan

来源：

RADIATION ONCOLOGY | 2014年 / 9卷

关键词：

Mucosal melanoma; Proton beam therapy; Radiotherapy; Sinonasal melanoma; NASAL CAVITY; HEAD; RADIOTHERAPY; NECK;

D O I：

10.1186/1748-717X-9-162

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: The significance of definitive radiotherapy for sinonasal mucosal melanoma (SMM) is sill controvertial. This study was to evaluate the role of high-dose proton beam therapy (PBT) in patients with SMM. Methods: The cases of 20 patients with SMM localized to the primary site who were treated by PBT between 2006 and 2012 were retrospectively analyzed. The patterns of overall survival and morbidity were assessed. Results: The median follow-up time was 35 months (range, 6-77 months). The 5-year overall and disease-free survival rates were 51% and 38%, respectively. Four patients showed local failure, 2 showed regrowth of the primary tumor, and 2 showed new sinonasal tumors beyond the primary site. The 5-year local control rate after PBT was 62%. Nodal and distant failure was seen in 7 patients. Three grade 4 late toxicities were observed in tumor-involved optic nerve. Conclusion: Our findings suggested that high-dose PBT is an effective local treatment that is less invasive than surgery but with comparable outcomes.

引用

页数：7

共 17 条

[11] Primary mucosal malignant melanoma of the head and neck [J].

Patel, SG ;

Prasad, ML ;

Escrig, M ;

Singh, B ;

Shaha, AR ;

Kraus, DH ;

Boyle, JO ;

Huvos, AG ;

Busam, K ;

Shah, JP .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2002, 24 (03) :247-257

[12]

Stern SJ, 1991, HEAD NECK-J SCI SPEC, V27, P13

[13] PROTON-BEAMS IN RADIATION-THERAPY [J].

SUIT, H ;

URIE, M .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (03) :155-164

[14] Sinonasal tract and nasopharyngeal melanomas - A clinicopathologic study of 115 cases with a proposed staging system [J].

Thompson, LDR ;

Wieneke, JA ;

Miettinen, M .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (05) :594-611

[15] Tumor Location Predicts Survival in Cutaneous Head and Neck Melanoma [J].

Tseng, Warren H. ;

Martinez, Steve R. .

JOURNAL OF SURGICAL RESEARCH, 2011, 167 (02) :192-198

[16] MUCOSAL MALIGNANT MELANOMA OF THE HEAD AND NECK TREATED BY CARBON ION RADIOTHERAPY [J].

Yanagi, Takeshi ;

Mizoe, Jun-Etsu ;

Hasegawa, Azusa ;

Takagi, Ryo ;

Bessho, Hiroki ;

Onda, Takeshi ;

Kamada, Tadashi ;

Okamoto, Yoshitaka ;

Tsujii, Hirohiko .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 74 (01) :15-20

[17] PROTON BEAM THERAPY AS A NONSURGICAL APPROACH TO MUCOSAL MELANOMA OF THE HEAD AND NECK: A PILOT STUDY [J].

Zenda, Sadamoto ;

Kawashima, Mitsuhiko ;

Nishio, Teiji ;

Kohno, Ryosuke ;

Nihei, Keiji ;

Onozawa, Masakatsu ;

Arahira, Satoko ;

Ogino, Takashi .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 81 (01) :135-139

← 1 2 →