Small-Molecule Porphyrin-Based Organic Nanoparticles with Remarkable Photothermal Conversion Efficiency for in Vivo Photoacoustic Imaging and Photothermal Therapy

被引:118
作者
Wu, Fengshou [1 ]
Chen, Li [1 ]
Yue, Liangliang [1 ]
Wang, Kai [3 ]
Cheng, Kai [6 ]
Chen, Jun [2 ]
Luo, Xiaogang [1 ]
Zhang, Tao [4 ,5 ]
机构
[1] Wuhan Inst Technol, Sch Chem Engn & Pharm, Key Lab Green Chem Proc, Minist Educ, Wuhan 430072, Hubei, Peoples R China
[2] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China
[3] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Wuhan 430062, Hubei, Peoples R China
[4] South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[5] South China Normal Univ, Coll Biophoton, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China
[6] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Hubei, Peoples R China
基金
中国国家自然科学基金;
关键词
porphyrin; self-assembly; photoacoustic imaging; photothermal therapy; organic nanoparticles; SOLAR-CELLS; CARBON DOTS; PHOTOSENSITIZERS; NANOMATERIALS; ABSORPTION; NANOSHEETS; VITRO; ACID;
D O I
10.1021/acsami.9b06866
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Near-infrared (NIR)-absorbing organic nanoparticles (ONPs) are emerging candidates for "one-for-all" theranostic nanomaterials with considerations of safety and formulation in mind. However, facile fabrication methods and improvements in the photothermal conversion efficiency (PCE) and photostability are likely needed before a clinically viable set of candidates emerges. Herein, a new organic compound, [porphyrin-diketopyrrolopyrrole (Por-DPP)] with the donor-acceptor structure was synthesized, where porphyrin was used as a donor unit while diketopyrrolopyrrole was used as an acceptor unit. Por-DPP exhibited efficient absorption extending from visible to NIR regions. After self-assembling into nanoparticles (NPs) (similar to 120 nm), the absorption spectrum of Por-DPP NPs broadened and red-shifted to some extent, relative to that of organic molecules. Furthermore, the architecture of NPs enhanced the acceptor-donor structure, leading to emission quenching and facilitating nonradiative thermal generation. The PCE of Por-DPP NPs was measured and calculated to be 62.5%, higher than most of ONPs. Under 808 nm laser irradiation, the Por-DPP NPs possessed a distinct photothermal therapy (PTT) effect in vitro and can damage cancer cells efficiently in vivo without significant side effects after phototherapy. Thus, the small-molecule porphyrin-based ONPs with high PCE demonstrated promising application in photoacoustic imaging-guided PTT.
引用
收藏
页码:21408 / 21416
页数:9
相关论文
共 52 条
[1]   Diketopyrrolopyrrole-Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic/Photothermal Synergistic Tumor Therapy [J].
Cai, Yu ;
Liang, Pingping ;
Tang, Qianyun ;
Yang, Xiaoyan ;
Si, Weili ;
Huang, Wei ;
Zhang, Qi ;
Dong, Xiaochen .
ACS NANO, 2017, 11 (01) :1054-1063
[2]   Photoacoustic Imaging Guided Near-Infrared Photothermal Therapy Using Highly Water-Dispersible Single-Walled Carbon Nanohorns as Theranostic Agents [J].
Chen, Daiqin ;
Wang, Chao ;
Nie, Xin ;
Li, Shumu ;
Li, Ruimin ;
Guan, Mirong ;
Liu, Zhuang ;
Chen, Chunying ;
Wang, Chunru ;
Shu, Chunying ;
Wan, Lijun .
ADVANCED FUNCTIONAL MATERIALS, 2014, 24 (42) :6621-6628
[3]   Highly absorbing multispectral near-infrared polymer nanoparticles from one conjugated backbone for photoacoustic imaging and photothermal therapy [J].
Chen, Haobin ;
Zhang, Jian ;
Chang, Kaiwen ;
Men, Xiaoju ;
Fang, Xiaofeng ;
Zhou, Libo ;
Li, Dongliang ;
Gao, Duyang ;
Yin, Shengyan ;
Zhang, Xuanjun ;
Yuan, Zhen ;
Wu, Changfeng .
BIOMATERIALS, 2017, 144 :42-52
[4]   Receptor and Microenvironment Dual-Recognizable Nanogel for Targeted Chemotherapy of Highly Metastatic Malignancy (vol 17, pg 4526, 2017) [J].
Chen, Jinjin ;
Ding, Jianxun ;
Xu, Weiguo ;
Sun, Tianmeng ;
Xiao, Haihua ;
Zhuang, Xiuli ;
Chen, Xuesi .
NANO LETTERS, 2017, 17 (08) :5180-5180
[5]   High-Security Nanocluster for Switching Photodynamic Combining Photothermal and Acid-Induced Drug Compliance Therapy Guided by Multimodal Active-Targeting Imaging [J].
Cheng, Kai ;
Yang, Xiao-Quan ;
Zhang, Xiao-Shuai ;
Chen, Jun ;
An, Jie ;
Song, Yuan-Yang ;
Li, Cheng ;
Xuan, Yang ;
Zhang, Ruo-Yun ;
Yang, Chun-Hua ;
Song, Xian-Lin ;
Zhao, Yuan-Di ;
Liu, Bo .
ADVANCED FUNCTIONAL MATERIALS, 2018, 28 (36)
[6]   Functional Nanomaterials for Phototherapies of Cancer [J].
Cheng, Liang ;
Wang, Chao ;
Feng, Liangzhu ;
Yang, Kai ;
Liu, Zhuang .
CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939
[7]   Light-Triggered Assembly of Gold Nanoparticles for Photothermal Therapy and Photoacoustic Imaging of Tumors In Vivo [J].
Cheng, Xiaju ;
Sun, Rui ;
Yin, Ling ;
Chai, Zhifang ;
Shi, Haibin ;
Gao, Mingyuan .
ADVANCED MATERIALS, 2017, 29 (06)
[8]   Fluorescent nanogel based on four-arm PEG-PCL copolymer with porphyrin core for bioimaging [J].
Dong, Xia ;
Wei, Chang ;
Lu, Li ;
Liu, Tianjun ;
Lv, Feng .
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 61 :214-219
[9]   In Vivo Imaging-Guided Photothermal/Photoacoustic Synergistic Therapy with Bioorthogonal Metabolic Glycoengineering-Activated Tumor Targeting Nanoparticles [J].
Du, Lihua ;
Qin, Huan ;
Ma, Teng ;
Zhang, Tao ;
Xing, Da .
ACS NANO, 2017, 11 (09) :8930-8943
[10]   Charge-Convertible Carbon Dots for Imaging Guided Drug Delivery with Enhanced in Vivo Cancer Therapeutic Efficiency [J].
Feng, Tao ;
Ai, Xiangzhao ;
An, Guanghui ;
Yang, Piaoping ;
Zhao, Yanli .
ACS NANO, 2016, 10 (04) :4410-4420