Peripheral blood stem cell yield calculated using preapheresis absolute CD34+cell count, peripheral blood volume processed, and donor body weight accurately predicts actual yield at multiple centers

被引:26
作者
Hosing, Chitra [1 ]
Saliba, Rima M. [1 ]
Hamerschlak, Nelson [2 ,3 ]
Kutner, Jose Mauro [2 ,3 ]
Sakashita, Araci Massami [2 ,3 ]
Kondo, Andrea Tiemi [2 ,3 ]
Rodrigues, Morgani [2 ,3 ]
Fernande, Juliana Folloni [2 ,3 ]
Chiattone, Alexandre [1 ]
Chiattone, Viviane C. [1 ]
Barros, Jose C. [4 ]
Chiattone, Carlos S. [4 ]
Chiattone, Ricardo [4 ]
Popat, Uday [1 ]
Qazilbash, Muzaffar [1 ]
Tang, Xiao Wen [5 ]
Wu, Depei [5 ]
Majilis, Alejandro [6 ]
de Lima, Marcos [7 ,8 ]
Anguita, Timoleon [6 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA
[2] Hosp Israelita Albert Einstein, Dept Hematol, Sao Paulo, Brazil
[3] Hosp Israelita Albert Einstein, Dept Hemotherapy & Cellular Therapy, Sao Paulo, Brazil
[4] Santa Casa Med Sch, Dept Hematol & Oncol, Sao Paulo, Brazil
[5] Soochow Univ, Dept Hematol, Affiliated Hosp 1,Minist Hlth, Jiangsu Inst Hematol,Key Lab Thrombosis & Hemosta, Suzhou, Peoples R China
[6] Clin Alemana, Dept Hematol, Santiago, Chile
[7] Case Western Reserve Univ, Dept Med, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA
[8] Case Western Reserve Univ, Case Comprehens Canc Ctr, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA
基金
中国国家自然科学基金;
关键词
MOBILIZATION; COLLECTION; TRANSPLANTATION; EFFICIENCY; APHERESIS; MYELOMA;
D O I
10.1111/trf.12435
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundAccurate prediction of stem cell yield is important for planning leukapheresis procedures. A formula has been published (Pierelli etal., Vox Sang 2006;91:126-34) to estimate the CD34+ dose collected on the first day of leukapheresis that was based on the preapheresis peripheral blood (PB) CD34+ counts, the blood volume processed, and the donor's weight. The aim of this study was to assess the predictive value of this formula. Study Design and MethodsData were retrospectively collected on 1126 consecutive PB stem cell harvests conducted at five institutions. Information on age, sex, diagnosis, weight, preapheresis absolute peripheral CD34+ count, total blood volume processed, and CD34+ cells harvested per kilogram of body weight on the first day of apheresis was collected. ResultsAmong donors at least 18 years old, Pearson's correlation coefficient (r) between actual yield (AY) and predicted yield (PY) was 0.76. To characterize this correlation, AY and PY were classified as being within the conventionally acceptable CD34+ doses (>2x10(6)-5x10(6) cells/kg), below this range (2x10(6) cells/kg), or above it (>5x10(6) cells/kg). The positive predictive value (PPV) of PY was estimated considering the distribution of AY as the gold standard. PPV was relatively high for PY of more than 5x10(6) cells/kg (85%), moderate for PY of not more than 2x10(6) cells/kg (72%), and low for PY more than 2x10(6) to 5x10(6) cells/kg (56%). A consistent pattern was observed within institutions. ConclusionThe formula of Pierelli etal. is associated with a PPV that is high, moderate, and relatively low for the corresponding predicted CD34+ doses.
引用
收藏
页码:1081 / 1087
页数:7
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