Alopecia neoplastica as a sign of visceral malignancies: a systematic review

被引:15
作者
Paolino, G. [1 ,2 ]
Pampena, R. [3 ]
Grassi, S. [2 ]
Mercuri, S. R. [1 ]
Cardone, M. [2 ]
Corsetti, P. [2 ]
Moliterni, E. [2 ]
Muscianese, M. [2 ]
Rossi, A. [2 ]
Frascione, P. [4 ]
Longo, C. [3 ,5 ]
机构
[1] IRCCS San Raffaele Hosp, Dermatol & Cosmetol, Milan, Italy
[2] Univ Roma La Sapienza, Dept Dermatol, Rome, Italy
[3] Azienda Unit Sanit Locale IRCCS Reggio Emilia, Ctr Oncol Ad Alta Tecnol Diagnost, Reggio Emilia, Italy
[4] IRCCS, San Gallicano Dermatol Inst, Dept Oncol & Preventat Dermatol, Rome, Italy
[5] Univ Modena & Reggio Emilia, Dermatol Unit, Reggio Emilia, Italy
关键词
RENAL-CELL CARCINOMA; METASTATIC BREAST-CARCINOMA; 1ST CLINICAL SIGN; CUTANEOUS METASTASIS; SCALP METASTASIS; RETROPERITONEAL LEIOMYOSARCOMA; NEUROENDOCRINE CARCINOMA; PRESENTING FEATURE; THYROID-CARCINOMA; SKULL METASTASIS;
D O I
10.1111/jdv.15498
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Alopecia neoplastica (AN) from visceral tumours is a rare form of cutaneous metastasis in which internal malignancies spread to the scalp. The diagnosis of AN may be very challenging, especially when its onset precedes the diagnosis of the primary tumour. We aimed to improve the knowledge on AN, highlighting that in case of scarring localized alopecia, a differential diagnosis with metastasis should always be considered. We performed a systematic review to describe the main demographic and clinical features associated with AN from visceral malignancies; a survival analysis was also performed. In 118 reports, accounting for 123 patients, we found that women were more affected by AN than men (53.7% vs. 46.3%). The most frequent site of the primary tumour was the gastrointestinal tract (24.4%), followed by breast (17.9%), kidney (8.1%), lung (7.3%), thyroid (7.3%), uterus (6.5%), central nervous system (6.5%), liver (3.3%) and other anatomic areas for 18.7% of cases. Furthermore, in more than half of the cases (66.1%), AN lesions were single and were mainly diagnosed after the primary visceral tumour (71.5%). Finally, survival analysis highlighted a lower progression-free survival in men; while, no significant differences in overall survival were reported among genders. In conclusion, metastatic skin disease should always be taken into consideration when dealing with patients with localized scarring alopecia.
引用
收藏
页码:1020 / 1028
页数:9
相关论文
共 126 条
[1]   Cutaneous metastasis as a first presentation for lung adenocarcinoma [J].
Abdeen, Yazan ;
Amireh, Sawsan ;
Patel, Alpa ;
Al-Halawani, Moh'd ;
Shaaban, Hamid ;
Miller, Richard .
NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, 2016, 8 (05) :222-225
[2]  
Aguiar H.R., 2016, JPRAS Open, V7, P27, DOI [10.1016/j.jpra.2015.10.002, DOI 10.1016/J.JPRA.2015.10.002]
[3]   LEIOMYOSARCOMA, METASTATIC TO SCALP FROM PRIMARY IN RETROPERITONEAL AREA - REPORT OF A CASE [J].
AKERS, WA ;
PRAZAK, G .
ARCHIVES OF DERMATOLOGY, 1960, 81 (06) :953-957
[4]   LEIOMYOSARCOMA METASTATIC TO THE BACK AND SCALP FROM A PRIMARY NEOPLASM IN THE UTERUS [J].
ALESSI, E ;
INNOCENTI, M ;
SALA, F .
AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1985, 7 (05) :471-476
[5]  
Allan RS, 2004, J NEUROL NEUROSUR PS, V75, P559
[6]   ALOPECIA-NEOPLASTICA RESPONSIVE TO TAMOXIFEN [J].
ARCHER, CB ;
SMITH, NP .
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1990, 83 (10) :647-648
[7]   Choroidal and skin metastases from papillary thyroid cancer: Case and a review of the literature [J].
Avram, AM ;
Gielczyk, R ;
Su, L ;
Vine, AK ;
Sisson, JC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (11) :5303-5307
[8]   A rare clinical manifestation of rectal adenocarcinoma and synchronous scalp metastasis: A case report [J].
Balta, Ahmet Ziya ;
Sucullu, Ilker ;
Ozdemir, Yavuz ;
Dandin, Ozgur .
TURKISH JOURNAL OF SURGERY, 2013, 29 (04) :197-199
[9]   Cutaneous scalp metastases from retroperitoneal leiomyosarcoma: a case report [J].
Baltz, Rebekah G. ;
Kaley, Jennifer R. ;
Hull, Cheryl A. ;
Gardner, Jerad M. .
JOURNAL OF CUTANEOUS PATHOLOGY, 2014, 41 (08) :680-685
[10]   ALOPECIA NEOPLASTICA - A RARE FORM OF CUTANEOUS METASTASIS [J].
BAUM, EM ;
OMURA, EF ;
PAYNE, RR ;
LITTLE, WP .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1981, 4 (06) :688-694