Intersection of cardiovascular disease and kidney disease: atrial fibrillation

被引：24

作者：

Bansal, Nisha ^{[1
]}

Hsu, Chi-yuan ^{[2
]}

Go, Alan S. ^{[3
]}

机构：

[1] Univ Washington, Kidney Res Inst, Seattle, WA 98104 USA

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

[3] Kaiser Permanente No Calif, Oakland, CA USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2014年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

chronic kidney disease; atrial fibrillation; end-stage renal disease; LEFT-VENTRICULAR HYPERTROPHY; C-REACTIVE PROTEIN; HEMODIALYSIS-PATIENTS; RENAL-FUNCTION; ECHOCARDIOGRAPHIC PARAMETERS; INTRACEREBRAL HEMORRHAGE; SYSTEMIC EMBOLISM; BLEEDING-TIME; RISK-FACTORS; STROKE;

D O I：

10.1097/01.mnh.0000444820.80249.56

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of review Atrial fibrillation is the most common sustained arrhythmia in patients with kidney disease. The purpose of this review is to describe the burden of atrial fibrillation in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), postulate possible mechanisms to explain this burden of disease, understand the clinical consequences of atrial fibrillation and review the treatment options for atrial fibrillation specific to patients with kidney disease. Recent findings Recent literature has revealed that the clinical multiorgan impact of atrial fibrillation in patients with CKD and ESRD is substantial. Although novel oral anticoagulants to treat atrial fibrillation and prevent associated complications have been tested in large trials in the general population, there is a paucity of data on the efficacy and safety of these agents in patients with advanced CKD and ESRD. Atrial fibrillation is a significant comorbidity in patients with CKD and ESRD with important prognostic implications. More research is needed to understand the mechanisms that contribute to the disproportionate burden of this arrhythmia in patients with kidney disease and in to treatment options specific to this population of high-risk patients.

引用

页码：275 / 282

页数：8

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