Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

被引：141
作者：
Distler, M. [1 ]
Aust, D. [2 ]
Weitz, J. [1 ]
Pilarsky, C. [1 ]
Gruetzmann, Robert [1 ]
机构：
[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus Dresden, Dept Visceral Thorac & Vasc Surg, D-01307 Dresden, Germany
[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus Dresden, Inst Pathol, D-01307 Dresden, Germany
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
关键词：
PAPILLARY-MUCINOUS NEOPLASMS; K-RAS MUTATIONS; INTRAEPITHELIAL NEOPLASIA; CYSTIC NEOPLASMS; GNAS MUTATIONS; CLINICOPATHOLOGICAL FEATURES; INTRADUCTAL NEOPLASIAS; ADJUVANT CHEMOTHERAPY; SURGICAL RESECTION; INTESTINAL PATHWAY;
D O I：
10.1155/2014/474905
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.
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页数：11
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