The Role of Autophagy in Osteoarthritis

被引：143
作者：
Duan, Ran [1 ,2 ]
Xie, Hui [1 ,2 ,3 ,4 ,5 ,6 ]
Liu, Zheng-Zhao [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Movement Syst Injury & Repair Res Ctr, Changsha, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Sports Med, Changsha, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Dept Orthoped, Changsha, Peoples R China
[4] Hunan Key Lab Organ Injury Aging & Regenerat Med, Changsha, Peoples R China
[5] Hunan Key Lab Bone Joint Degenerat & Injury, Changsha, Peoples R China
[6] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
基金：
中国国家自然科学基金;
关键词：
apoptosis; autophagy; cartilage; chondrocyte; osteoarthritis; MITOCHONDRIAL DYSFUNCTION; TARGETED DELETION; CARTILAGE; CHONDROCYTES; STRESS; PROLIFERATION; GROWTH; EPIDEMIOLOGY; PATHOGENESIS; ACTIVATION;
D O I：
10.3389/fcell.2020.608388
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Chondrocytes are the only cell type in normal cartilage. The pathological changes of osteoarthritis (OA) mostly revolve around the apoptosis and dysfunction of chondrocytes. Autophagy, as an intracellular degradation system that maintains the steady state of energy metabolism in cells, has been shown to restore the function of damaged chondrocytes, alleviating the occurrence and progression of OA. In this review, we explored the relationship between autophagy and OA and the key molecules of autophagy pathway that regulate the progression of OA, providing new ideas for OA treatment by targeting autophagy.
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页数：9
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