A Novel Wireless Left Atrial Pressure Monitoring System for Patients with Heart Failure, First Ex-Vivo and Animal Experience

被引：26

作者：

Perl, Leor ^{[1
,2
]}

Soifer, Elina ^{[3
]}

Bartunek, Jozef ^{[4
]}

Erdheim, Dedi ^{[3
]}

Koehler, Friedrich ^{[5
]}

Abraham, William T. ^{[6
]}

Meerkin, David ^{[7
,8
]}

机构：

[1] Rabin Med Ctr, Div Cardiol, 39 Jabotinsky St, Petah Tiqwa, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[3] Vectorious Med Technol, 24 Raul Wallenberg St, Tel Aviv, Israel

[4] Onze Lieve Vrouwziekenhuis OLV Hosp, Cardiovasc Ctr, Moorselbaan 164, B-9300 Aalst, Belgium

[5] Charite Univ Med Berlin, Ctr Cardiovasc Telemed, Dept Cardiol & Angiol, Campus Mitte, Berlin, Germany

[6] Ohio State Univ, Div Cardiovasc Med, 473 West 12th Ave, Columbus, OH 43210 USA

[7] Shaare Zedek Med Ctr, Dept Cardiol, Jerusalem, Israel

[8] Padeh Poriya Med Ctr, Dept Cardiol, Jerusalem, Israel

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2019年 / 12卷 / 04期

关键词：

Heart failure exacerbation; Hemodynamics; Left atrial pressure; Telemonitoring; PULMONARY-ARTERY PRESSURE; HOSPITALIZATIONS; MANAGEMENT; MORTALITY; THERAPY; IMPACT;

D O I：

10.1007/s12265-018-9856-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The V-LAP (TM) measures left atrial pressure (LAP) and enables bi-directional communications with an external unit, designed to monitor heart failure patients. We hereby describe the pre-clinical experience. Following an ex vivo phase, the system was implanted at the interatrial septum of 10 ovine subjects. LAP readouts were compared with pulmonary capillary wedge pressure (PCWP) at index procedure and 1, 2 and 3-6 months after the implantation, at rest and after volume loading. Histopathology assessment (n = 8) was performed up to 50 weeks post procedure. Procedural success was 100%. Measurements showed a mean difference of 0.19 +/- 2.51 mmHg. During this period, correlation of V-LAP (TM) with PCWP was excellent (R-2 = 0.95, for 119 total measurements). There were no major adverse events related to the V-LAP (TM) system. In an animal model, the implantation of the novel wireless left atrial pressure sensor V-LAP (TM) was feasible, safe, and showed good accuracy and precision.

引用

页码：290 / 298

页数：9

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