Minocycline as a potential therapeutic agent in neurodegenerative disorders characterised by protein misfolding

被引：52
作者：
Noble, Wendy [1 ]
Garwood, Claire J. [1 ]
Hanger, Diane P. [1 ]
机构：
[1] Kings Coll London, Inst Psychiat, Dept Neurosci, MRC Ctr Neurodegenerat Res, London SE5 8AF, England
来源：
PRION | 2009年 / 3卷 / 02期
关键词：
minocycline; protein aggregation; neuroinflammation; neurodegeneration; protein misfolding; AMYOTROPHIC-LATERAL-SCLEROSIS; SLOWS DISEASE PROGRESSION; MOUSE MODEL; MICROGLIAL ACTIVATION; PRION PROTEIN; CELL-DEATH; A-BETA; ALZHEIMERS; TAU; TETRACYCLINES;
D O I：
10.4161/pri.3.2.8820
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Many neurodegenerative disorders share common features including the accumulation of aggregated misfolded proteins, neuroinflammation and the induction of apoptosis. While the contributions of each of these individual elements to neuronal death remain unclear, a commonly used antibiotic, minocycline, has been shown to reduce the progression and severity of disease in several models of neurodegeneration by variously downregulating these molecular pathways. Here we discuss the evidence for the potential of minocycline as a broad-specificity therapeutic agent for those neurodegenerative diseases that are characterized by the presence of misfolded proteins.
引用
收藏
页码：78 / 83
页数：6
相关论文
共 71 条
  • [1] Minocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
    Alano, Conrad C.
    Kauppinen, Tiina M.
    Valls, Andreu Viader
    Swanson, Raymond A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (25) : 9685 - 9690
  • [2] A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
    Amin, AR
    Attur, MG
    Thakker, GD
    Patel, PD
    Vyas, PR
    Patel, RN
    Patel, IR
    Abramson, SB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (24) : 14014 - 14019
  • [3] Blockade of PKCδ proteolytic activation by loss of function mutants rescues mesencephalic dopaminergic neurons from methylcyclopentadienyl manganese tricarbonyl (MMT)-induced apoptotic cell death
    Anantharam, V
    Kitazawa, M
    Latchoumycandane, C
    Kanthasamy, A
    Kanthasamy, AG
    [J]. PROTECTIVE STRATEGIES FOR NEURODEGENERATIVE DISEASES, 2004, 1035 : 271 - 289
  • [4] Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
    Anderson, John P.
    Walker, Donald E.
    Goldstein, Jason M.
    de laat, Rian
    Banducci, Kelly
    Caccavello, Russell J.
    Barbour, Robin
    Huang, Jiping
    Kling, Kristin
    Lee, Michael
    Diep, Linnea
    Keim, Pamela S.
    Shen, Xiaofeng
    Chataway, Tim
    Schlossmacher, Michael G.
    Seubert, Peter
    Schenk, Dale
    Sinha, Sukanto
    Gai, Wei Ping
    Chilcote, Tamie J.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (40) : 29739 - 29752
  • [5] Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
    Andorfer, C
    Kress, Y
    Espinoza, M
    de Silva, R
    Tucker, KL
    Barde, YA
    Duff, K
    Davies, P
    [J]. JOURNAL OF NEUROCHEMISTRY, 2003, 86 (03) : 582 - 590
  • [6] Tau, tangles, and Alzheimer's disease
    Binder, LI
    Guillozet-Bongaarts, AL
    Garcia-Sierra, F
    Berry, RW
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2005, 1739 (2-3): : 216 - 223
  • [7] Clinical potential of minocycline for neurodegenerative disorders
    Blum, D
    Chtarto, A
    Tenenbaum, L
    Brotchi, J
    Levivier, M
    [J]. NEUROBIOLOGY OF DISEASE, 2004, 17 (03) : 359 - 366
  • [8] Reduced retina microglial activation and improved optic nerve integrity with minocycline treatment in the DBA/2J mouse model of glaucoma
    Bosco, Alejandra
    Inman, Denise M.
    Steele, Michael R.
    Wu, Guangming
    Soto, Ileana
    Marsh-Armstrong, Nicholas
    Hubbard, Walter C.
    Calkins, David J.
    Horner, Philip J.
    Vetter, Monica L.
    [J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2008, 49 (04) : 1437 - 1446
  • [9] Programmed cell death mechanisms in neurological disease
    Bredesen, Dale E.
    [J]. CURRENT MOLECULAR MEDICINE, 2008, 8 (03) : 173 - 186
  • [10] Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
    Bruijn, LI
    Houseweart, MK
    Kato, S
    Anderson, KL
    Anderson, SD
    Ohama, E
    Reaume, AG
    Scott, RW
    Cleveland, DW
    [J]. SCIENCE, 1998, 281 (5384) : 1851 - 1854
12345678