Evidence that the number of hematopoietic stem cells per animal is conserved in mammals

被引：167

作者：

Abkowitz, JL

Catlin, SN

McCallie, MT

Guttorp, P

机构：

[1] Univ Washington, Div Hematol, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Stat, Seattle, WA 98195 USA

[3] Univ Nevada, Dept Math Sci, Las Vegas, NV 89154 USA

来源：

BLOOD | 2002年 / 100卷 / 07期

关键词：

D O I：

10.1182/blood-2002-03-0822

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Humans and larger mammals require more blood cells per lifetime than mice because of their larger size and longer life expectancy. To investigate this evolutionary adaptation, we calculated the total number of nucleated marrow cells (NMCs) per cat, observing the distribution of Fe-59 to marrow, then multiplied this value (1.9 +/- 0.9 x 10(10) [mean +/- SD]) times the frequency of feline hematopoietic stem cells (HSCs) (6 HSCs/10(7) NMCs) to derive the total number of HSCs per cat (11 400 +/- 5400). Surprisingly, when the total number of HSCs per mouse was calculated with a similar experimental and computational approach, the value was equivalent. These data imply that the output of differentiated cells per feline HSC must vastly exceed that of murine HSCs. Furthermore, if the total number of human HSCs were also equivalent to the total number of HSCs in cat and mouse, the frequency of human HSCs would be 0.7 to 1.5 HSCs/10(8) NMCs, a frequency that is 20-fold less than estimated by the NOD/SCID repopulating assay. (C) 2002 by The American Society of Hematology.

引用

页码：2665 / 2667

页数：3

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