Pharmacokinetics of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol and its active metabolite after oral and intravenous administration in rat

被引：20
作者：
Zhang, X. [1 ]
Xu, J. [1 ]
Zhang, D. [2 ]
Gu, J. [2 ]
Zhao, Y. [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Shenyang 110016, Peoples R China
[2] Jilin Univ, Res Ctr Drug Metab, Changchun 130023, Peoples R China
来源：
XENOBIOTICA | 2009年 / 39卷 / 06期
关键词：
20(S)-25-methoxyl-dammarane-3 beta; 12; beta; 20-triol (25-OCH3-PPD); 25-OH-PPD; liquid chromatography-tandem mass spectroscopy (HPLC-MS-MS); active metabolite; pharmacokinetics; CHROMATOGRAPHY-MASS SPECTROMETRY; SOLID-PHASE EXTRACTION; PANAX-NOTOGINSENG; NATURAL-PRODUCT; IN-VITRO; INTESTINAL BACTERIA; GINSENOSIDE RG3; PLASMA; 20(S)-GINSENOSIDE; BIOAVAILABILITY;
D O I：
10.1080/00498250902810951
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. The pharmacokinetics behaviour of 20(S)-25-methoxyl-dammarane-3 beta, 12 beta, 20-triol (25-OCH3-PPD) and its active metabolite after oral and intravenous administration in rats were studied. 2. Rats were administered 2.5, 5.0, and 10 mg kg(-1) 25-OCH3-PPD orally after an overnight fasting or by intravenous injection of 5 mg kg(-1) 25-OCH3-PPD via the tail vein. Plasma concentration-time profiles of 25-OCH3-PPD and its active metabolite 25-O-demethylated (25-OH-PPD) in rats were monitored by liquid chromatography-tandem mass spectroscopy (HPLC-MS-MS). 3. The 25-O-demethylated metabolite appears to be a pathway in the phase I metabolism of 25-OCH3-PPD in rats. The plasma concentration of the metabolite was higher than that of the parent compound.
引用
收藏
页码：457 / 464
页数：8
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