Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems

被引：32

作者：

de Jesus Oliveira, Antonia Carla ^{[1
]}

Chaves, Luise Lopes ^{[1
]}

Silva Ribeiro, Fabio de Oliveira ^{[2
]}

Monteiro de Lima, Lais Ramos ^{[3
]}

Oliveira, Thaisa Cardoso ^{[1
]}

Garcia-Villen, Fatima ^{[4
]}

Viseras, Cesar ^{[4
,5
]}

de Paula, Regina C. M. ^{[3
]}

Rolim-Neto, Pedro Jose ^{[6
]}

Hallwass, Fernando ^{[7
]}

Silva-Filho, Edson C. ^{[8
]}

da Silva, Durcilene Alves ^{[2
]}

Soares-Sobrinho, Jose Lamartine ^{[1
]}

de la Roca Soares, Monica Felts ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, Qual Control Core Med & Correlates NCQMC, Recife, PE, Brazil

[2] Fed Univ Delta Parnaiba, Res Ctr Biodivers & Biotechnol BIOTEC, Parnaiba, PI, Brazil

[3] Univ Fed Ceara, Dept Organ & Inorgan Chem, Fortaleza, Ceara, Brazil

[4] Univ Granada, Fac Pharm, Dept Pharm & Pharmaceut Technol, Granada, Spain

[5] CSIC UGR, Andalusian Inst Earth Sci, Granada, Spain

[6] Univ Fed Pernambuco, Lab Technol Med LTM, Recife, PE, Brazil

[7] Univ Fed Pernambuco, Dept Fundamental Chem, Recife, PE, Brazil

[8] Univ Fed Piaui, Interdisciplinary Lab Adv Mat LIMAV, Teresina, PI, Brazil

来源：

CARBOHYDRATE POLYMERS | 2021年 / 254卷

关键词：

Polysaccharides; Chemical modification; Microwave irradiation; Polymeric nanoparticles; Benznidazole; ANACARDIUM-OCCIDENTALE; CHITOSAN PHTHALATE; ORAL DELIVERY; MATRIX TABLETS; NANOPARTICLES; POLYSACCHARIDES; RELEASE; SUCCINATE; VARIABLES; VEHICLES;

D O I：

10.1016/j.carbpol.2020.117226

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical modification of polysaccharides is an important approach for their transformation into customized matrices that suit different applications. Microwave irradiation (MW) has been used to catalyze chemical reactions. This study developed a method of MW-initiated synthesis for the production of phthalated cashew gum (Phat-CG). The structural characteristics and physicochemical properties of the modified biopolymers were investigated by FTIR, GPC, H-1Y NMR, relaxometry, elemental analysis, thermal analysis, XRD, degree of substitution, and solubility. Phat-CG was used as a matrix for drug delivery systems using benznidazole (BNZ) as a model drug. BNZ is used in the pharmacotherapy of Chagas disease. The nanoparticles were characterized by size, PDI, zeta potential, AFM, and in vitro release. The nanoparticles had a size of 288.8 nm, PDI of 0.27, and zeta potential of -31.8 mV. The results showed that Phat-CG has interesting and promising properties as a new alternative for improving the treatment of Chagas disease.

引用

页数：10

共 83 条

[1] Synthesis and characterization of non-toxic and thermo-sensitive poly(N-isopropylacrylamide)-grafted cashew gum nanoparticles as a potential epirubicin delivery matrix [J].

Abreu, Clara M. W. S. ;

Paula, Haroldo C. B. ;

Seabra, Vitor ;

Feitosa, Judith P. A. ;

Sarmento, Bruno ;

de Paula, Regina C. M. .

CARBOHYDRATE POLYMERS, 2016, 154 :77-85

[2] Poly-epsilon-caprolactone nanoparticles enhance ursolic acid in vivo efficacy against Trypanosoma cruzi infection [J].

Abriata, Juliana Palma ;

Eloy, Josimar O. ;

Riul, Thalita Bachelli ;

Campos, Patricia Mazureki ;

Baruffi, Marcelo Dias ;

Marchetti, Juliana Maldonado .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 77 :1196-1203

[3] Evaluation of chitosan succinate and chitosan phthalate as enteric coating polymers for diclofenac sodium tablets [J].

Aiedeh, KM ;

Taha, MO ;

Al-Khatib, H .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2005, 15 (03) :207-211

[4] A dual-action chitosan-based nanogel system of triclosan and flurbiprofen for localised treatment of periodontitis [J].

Aminu, Nafiu ;

Chan, Siok-Yee ;

Yam, Mun-Fei ;

Toh, Seok-Ming .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2019, 570

[5] Development and evaluation of triclosan loaded poly-ε-caprolactone nanoparticulate system for the treatment of periodontal infections [J].

Aminu, Nafiu ;

Baboota, Sanjula ;

Pramod, K. ;

Singh, Manisha ;

Dang, Shweta ;

Ansari, Shahid H. ;

Sahni, Jasjeet K. ;

Ali, Javed .

JOURNAL OF NANOPARTICLE RESEARCH, 2013, 15 (11)

[6] Microwave-assisted synthesis and characterization of hydrophilically functionalized polygalacturonic acid [J].

Aris, Zarif Farhana Mohd ;

Bouldin, Ryan M. ;

Pelletier, Margery G. H. ;

Gaines, Peter ;

Budhlall, Bridgette ;

Nagarajan, Ramaswamy .

CARBOHYDRATE POLYMERS, 2017, 155 :432-439

[7] Effect of ionic strength and pH of dissolution media on theophylline release from hypromellose matrix tablets-Apparatus USP III, simulated fasted and fed conditions [J].

Asare-Addo, Kofi ;

Levina, Marina ;

Rajabi-Siahboomi, Ali R. ;

Nokhodchi, Ali .

CARBOHYDRATE POLYMERS, 2011, 86 (01) :85-93

[8] Invitro evaluations of free radical assisted microwave irradiated polyacrylamide grafted cashew gum (CG) biocompatible graft copolymer (CG-g-PAM) as effective polymeric scaffold [J].

Bal, Trishna ;

Yadav, Satyendra Kumar ;

Rai, Nikhil ;

Swain, Sabyasachi ;

Shambhavi ;

Garg, Sandeep ;

Sen, Gautam .

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 56

[9] Review of polysaccharide particle-based functional drug delivery [J].

Barclay, Thomas G. ;

Day, Candace Minhthu ;

Petrovsky, Nikolai ;

Garg, Sanjay .

CARBOHYDRATE POLYMERS, 2019, 221 :94-112

[10] Current drug therapy and pharmaceutical challenges for Chagas disease [J].

Bermudez, Jose ;

Davies, Carolina ;

Simonazzi, Analia ;

Pablo Real, Juan ;

Palma, Santiago .

ACTA TROPICA, 2016, 156 :1-16

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