Microwave-initiated rapid synthesis of phthalated cashew gum for drug delivery systems

被引：31

作者：

de Jesus Oliveira, Antonia Carla ^{[1
]}

Chaves, Luise Lopes ^{[1
]}

Silva Ribeiro, Fabio de Oliveira ^{[2
]}

Monteiro de Lima, Lais Ramos ^{[3
]}

Oliveira, Thaisa Cardoso ^{[1
]}

Garcia-Villen, Fatima ^{[4
]}

Viseras, Cesar ^{[4
,5
]}

de Paula, Regina C. M. ^{[3
]}

Rolim-Neto, Pedro Jose ^{[6
]}

Hallwass, Fernando ^{[7
]}

Silva-Filho, Edson C. ^{[8
]}

da Silva, Durcilene Alves ^{[2
]}

Soares-Sobrinho, Jose Lamartine ^{[1
]}

de la Roca Soares, Monica Felts ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharmaceut Sci, Qual Control Core Med & Correlates NCQMC, Recife, PE, Brazil

[2] Fed Univ Delta Parnaiba, Res Ctr Biodivers & Biotechnol BIOTEC, Parnaiba, PI, Brazil

[3] Univ Fed Ceara, Dept Organ & Inorgan Chem, Fortaleza, Ceara, Brazil

[4] Univ Granada, Fac Pharm, Dept Pharm & Pharmaceut Technol, Granada, Spain

[5] CSIC UGR, Andalusian Inst Earth Sci, Granada, Spain

[6] Univ Fed Pernambuco, Lab Technol Med LTM, Recife, PE, Brazil

[7] Univ Fed Pernambuco, Dept Fundamental Chem, Recife, PE, Brazil

[8] Univ Fed Piaui, Interdisciplinary Lab Adv Mat LIMAV, Teresina, PI, Brazil

来源：

CARBOHYDRATE POLYMERS | 2021年 / 254卷

关键词：

Polysaccharides; Chemical modification; Microwave irradiation; Polymeric nanoparticles; Benznidazole; ANACARDIUM-OCCIDENTALE; CHITOSAN PHTHALATE; ORAL DELIVERY; MATRIX TABLETS; NANOPARTICLES; POLYSACCHARIDES; RELEASE; SUCCINATE; VARIABLES; VEHICLES;

D O I：

10.1016/j.carbpol.2020.117226

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical modification of polysaccharides is an important approach for their transformation into customized matrices that suit different applications. Microwave irradiation (MW) has been used to catalyze chemical reactions. This study developed a method of MW-initiated synthesis for the production of phthalated cashew gum (Phat-CG). The structural characteristics and physicochemical properties of the modified biopolymers were investigated by FTIR, GPC, H-1Y NMR, relaxometry, elemental analysis, thermal analysis, XRD, degree of substitution, and solubility. Phat-CG was used as a matrix for drug delivery systems using benznidazole (BNZ) as a model drug. BNZ is used in the pharmacotherapy of Chagas disease. The nanoparticles were characterized by size, PDI, zeta potential, AFM, and in vitro release. The nanoparticles had a size of 288.8 nm, PDI of 0.27, and zeta potential of -31.8 mV. The results showed that Phat-CG has interesting and promising properties as a new alternative for improving the treatment of Chagas disease.

引用

页数：10

共 83 条

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