Two new thiophene polyacetylene glycosides from Atractylodes lancea

被引：20

作者：

Feng, Zi-Ming ^{[1
,2
]}

Xu, Kuo ^{[1
,2
]}

Wang, Wei ^{[3
]}

Du, Ning ^{[3
]}

Zhang, Jing-Hua ^{[3
]}

Yang, Ya-Nan ^{[1
,2
]}

Jiang, Jian-Shuang ^{[1
,2
]}

Zhang, Pei-Cheng ^{[1
,2
]}

机构：

[1] Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100050, Peoples R China

[3] Beijing Ctr Phys & Chem Anal, Beijing 100089, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2018年 / 20卷 / 06期

关键词：

Asteraceae; Atractylodes lancea; thiophene polyacetylene; atracthioenyneside A; atracthioenyneside B; absolute configuration; SPONGE PETROSIA SP; ACETYLENES; RHIZOMES; PLANTS; ACIDS; MODEL;

D O I：

10.1080/10286020.2018.1458841

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Phytochemical investigation on the rhizomes of Atractylodes lancea led to the isolation of two new thiophene polyacetylene glycosides (1 and 2) and six known compounds (3-8). Their structures were elucidated based on the extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of new compounds were established by calculated and experimental circular dichroism. All the compounds were assessed on the lipopolysaccharide-induced NO production in BV2 cells and compounds 3, 7, and 8 showed moderate inhibitory activities. [GRAPHICS] .

引用

页码：531 / 537

页数：7

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