Connecting with Ska, a key complex at the kinetochore-microtubule interface

被引：33

作者：

Guimaraes, Geoffrey J. ^{[1
]}

DeLuca, Jennifer G. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Biochem & Mol Biol, Ft Collins, CO 80523 USA

来源：

EMBO JOURNAL | 2009年 / 28卷 / 10期

关键词：

CENTROMERE; COMPONENT; SPINDLE;

D O I：

10.1038/emboj.2009.124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly orchestrated movements of chromosomes during mitosis depend on the formation of stable connections between microtubules and kinetochores. How kinetochores generate these linkages to harness the forces produced by dynamic microtubule plus-ends remains unknown. Three recent studies make significant progress on this front, by identifying a third component of the kinetochore-associated Ska (spindle and kinetochore associated) complex and demonstrating that the complex is required to generate stable kinetochore-microtubule attachments during mitosis in human cells.

引用

页码：1375 / 1377

页数：3

共 13 条

[1] Bub1 is essential for assembly of the functional inner centromere [J].

Boyarchuk, Yekaterina ;

Salic, Adrian ;

Dasso, Mary ;

Arnaoutov, Alexei .

JOURNAL OF CELL BIOLOGY, 2007, 176 (07) :919-928

[2] Phospho-regulation of kinetochore-microtubule attachments by the aurora kinase Ipl1p [J].

Cheeseman, LM ;

Anderson, S ;

Jwa, M ;

Green, EM ;

Kang, JS ;

Yates, JR ;

Chan, CSM ;

Drubin, DG ;

Barnes, G .

CELL, 2002, 111 (02) :163-172

[3] The Ndc80 complex: Hub of kinetochore activity [J].

Ciferri, Claudio ;

Musacchio, Andrea ;

Petrovic, Arsen .

FEBS LETTERS, 2007, 581 (15) :2862-2869

[4] Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3 [J].

Gaitanos, Thomas N. ;

Santamaria, Anna ;

Jeyaprakash, A. Arockia ;

Wang, Bin ;

Conti, Elena ;

Nigg, Erich A. .

EMBO JOURNAL, 2009, 28 (10) :1442-1452

[5] Dam1 complexes go it alone on disassembling microtubules [J].

Gardner, Melissa K. ;

Odde, David J. .

NATURE CELL BIOLOGY, 2008, 10 (04) :379-381

[6] Timely anaphase onset requires a novel spindle and kinetochore complex comprising Ska1 and Ska2 [J].

Hanisch, Anja ;

Sillje, Herman H. W. ;

Nigg, Erich A. .

EMBO JOURNAL, 2006, 25 (23) :5504-5515

[7] Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation [J].

Janke, C ;

Ortíz, J ;

Tanaka, TU ;

Lechner, J ;

Schiebel, E .

EMBO JOURNAL, 2002, 21 (1-2) :181-193

[8] Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle [J].

Jones, MH ;

He, XW ;

Giddings, TH ;

Winey, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13675-13680

[9] The Ndc80 Kinetochore Complex Forms Load-Bearing Attachments to Dynamic Microtubule Tips via Biased Diffusion [J].

Powers, Andrew F. ;

Franck, Andrew D. ;

Gestaut, Daniel R. ;

Cooper, Jeremy ;

Gracyzk, Beth ;

Wei, Ronnie R. ;

Wordeman, Linda ;

Davis, Trisha N. ;

Asbury, Charles L. .

CELL, 2009, 136 (05) :865-875

[10]

Shang C, 2003, MOL BIOL CELL, V14, P3342, DOI 10.1091/mbc.E02-11-0765

← 1 2 →