Three new highly-oxygenated metabolites from the endophytic fungus Cytospora rhizophorae A761

被引：31

作者：

Liu, Hong-Xin ^{[1
]}

Tan, Hai-Bo ^{[2
]}

Liu, Yuan ^{[1
]}

Chen, Yu-Chan ^{[1
]}

Li, Sai-Ni ^{[1
]}

Sun, Zhang-Hua ^{[1
]}

Li, Hao-Hua ^{[1
]}

Qiu, Sheng-Xiang ^{[2
]}

Zhang, Wei-Min ^{[1
]}

机构：

[1] Guangdong Inst Microbiol, Guangdong Open Lab Appl Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, State Key Lab Appl Microbiol Southern China, Guangzhou 510070, Peoples R China

[2] Chinese Acad Sci, Guangdong Prov Key Lab Appl Bot, Key Lab Plant Resources Conservat & Sustainable U, Program Nat Prod Chem Biol, South China Bot Garden, Guangzhou 510650, Peoples R China

来源：

FITOTERAPIA | 2017年 / 117卷

基金：

中国国家自然科学基金;

关键词：

Cytospora rhizophorae; Morinda officinalis; Highly-oxygenated metabolites; Cytosporaphenones A-C; Cytotoxicity; CHEMICAL-CONSTITUENTS; A-C; ROOTS; ANTHRAQUINONES; DERIVATIVES; MEROTERPENOIDS; COMPOUND; XANTHONE;

D O I：

10.1016/j.fitote.2016.12.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cytosporaphenones A-C, one new polyhydric benzophenone and two new naphtopyrone derivatives, along with eight known ones, Were isolated from Cytospora rhizophorae, an endophytic fungus from Morinda officinalis. Their structures were fully characterized by means of detailed spectroscopic analysis and X-ray single crystal diffraction. To our knowledge, the three new compounds were the most highly oxygenated metabolites of their families discovered in nature. Moreover, all of the compounds were evaluated for in vitro cytotokic activities against MCF7, NCI -H460, HepG-2 and SF -268 tumor cell lines, and the new compound 1 exhibited weak growth inhibitory activity against the tumor cell lines MCF-7 and HepG-2 with IC50 values of 70 and 60 mu M, respectively. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1 / 5

页数：5

共 32 条

[1] A xanthone and a phenylanthraquinone from the roots of Bulbine frutescens, and the revision of six seco-anthraquinones into xanthones [J].