Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists

被引：121

作者：

Kolibianakis, EM ^{[1
]}

Albano, C ^{[1
]}

Camus, M ^{[1
]}

Tournaye, H ^{[1
]}

Van Steirteghem, AC ^{[1
]}

Devroey, P ^{[1
]}

机构：

[1] Dutch Speaking Free Univ Brussels, Ctr Reprod Med, B-1090 Brussels, Belgium

来源：

FERTILITY AND STERILITY | 2004年 / 82卷 / 01期

关键词：

GnRH antagonists; recombinant FSH; human chorionic gonadotropin;

D O I：

10.1016/j.fertnstert.2004.01.027

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess the effect of altering the timing of hCG administration on ongoing pregnancy rates in patients stimulated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF. Design: Prospective, randomized, controlled trial. Setting: Tertiary referral center. Patient(s): Four hundred thirteen patients undergoing IVF. Intervention(s): Rec-FSH stimulation starting on day 2 of the cycle combined with daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10,000 IU of hCG either as soon as at least three follicles were 17 mm on ultrasound (early-hCG group, 208 patients) or 2 days later after this criterion was met (late-hCG group, 205 patients). Main Outcome Measure(s): Ongoing pregnancy rate. Result(s): Fertilization rates and number and quality of embryos transferred did not differ between the two groups. However, a significantly lower ongoing pregnancy rate was present in the late-hCG as compared with the early-hCG group (25.0% vs. 35.6%, respectively). Conclusion(s): Prolongation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated with a significantly lower ongoing pregnancy rate. (C) 2004 by American Society for Reproductive Medicine.

引用

页码：102 / 107

页数：6