Kank proteins: structure, functions and diseases

被引：78

作者：

Kakinuma, N. ^{[1
]}

Zhu, Y. ^{[1
]}

Wang, Y. ^{[1
]}

Roy, B. C. ^{[1
]}

Kiyama, R. ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Neurosci Res Inst, Signaling Mol Res Grp, Tsukuba, Ibaraki 3058566, Japan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2009年 / 66卷 / 16期

关键词：

Ankyrin-repeat; Coiled-coil motif; Tumor suppressor gene; Actin stress fiber; Nucleo-cytoplasmic shuttling; Renal cell carcinoma; Signal transduction; ACTIN STRESS FIBERS; ANKYRIN-REPEAT; HOMOZYGOUS DELETIONS; CELL CARCINOMA; RHO-GTPASES; GENE; IRSP53; IDENTIFICATION; EXPRESSION; 9P;

D O I：

10.1007/s00018-009-0038-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Kank family of proteins, Kank1-Kank4, are characterized by their unique structure, coiled-coil motifs in the N-terminal region, and ankyrin-repeats in the C-terminal region, with an additional motif, the KN motif, at the N-terminus. Kank1 was obtained by positional cloning of a tumor suppressor gene in renal cell carcinoma, while the other members were found by homology search. The family is involved in the regulation of actin polymerization and cell motility through signaling pathways containing PI3K/Akt and/or unidentified modulators/effectors. Their relationship to diseases such as cancer, and to neuronal and developmental disorders, will be an important subject of future study.

引用

页码：2651 / 2659

页数：9

共 53 条

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