Loss of heterozygosity on chromosome 17 and mutation of the p53 gene in retinoblastoma

被引:47
作者
Kato, MV
Shimizu, T
Ishizaki, K
Kaneko, A
Yandell, DW
Toguchida, J
Sasaki, MS
机构
[1] KYOTO UNIV,CTR RADIAT BIOL,SAKYO KU,KYOTO 606,JAPAN
[2] AICHI CANC CTR,RES INST,EXPT RADIOL LAB,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN
[3] NATL CANC CTR,DEPT OPHTHALMOL,CHUO KU,TOKYO 105,JAPAN
[4] UNIV VERMONT,DEPT PATHOL,BURLINGTON,VT 05405
[5] KYOTO UNIV,BIOMED ENGN RES CTR,SAKYO KU,KYOTO 606,JAPAN
关键词
retinoblastoma; loss of heterozygosity; chromosome; 17; p53;
D O I
10.1016/0304-3835(96)04305-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Loss of heterozygosity (LOH) on chromosome 17 and mutations of the p53 gene were examined in 25 retinoblastomas (RB), consisting of three familial tumors, nine hereditary tumors without family history, 11 non-hereditary tumors, one recurrent tumor and one lung-metastatic tumor. LOH on chromosome 17 was detected in only one of the 23 primary RB. No mutations of the p53 gene were detected in the primary tumors. A recurrent tumor showed LOH on the short arm region of chromosome 17. LOH on chromosome 17 and a point mutation of the p53 gene were also detected in a metastatic tumor. These results suggest that LOH on chromosome 17 and mutation of the p53 gene may not be associated with the development of primary RB, but may play a role in the progression of RB.
引用
收藏
页码:75 / 82
页数:8
相关论文
共 24 条
  • [1] CONTROL OF ANGIOGENESIS IN FIBROBLASTS BY P53 REGULATION OF THROMBOSPONDIN-1
    DAMERON, KM
    VOLPERT, OV
    TAINSKY, MA
    BOUCK, N
    [J]. SCIENCE, 1994, 265 (5178) : 1582 - 1584
  • [2] MICE DEFICIENT FOR P53 ARE DEVELOPMENTALLY NORMAL BUT SUSCEPTIBLE TO SPONTANEOUS TUMORS
    DONEHOWER, LA
    HARVEY, M
    SLAGLE, BL
    MCARTHUR, MJ
    MONTGOMERY, CA
    BUTEL, JS
    BRADLEY, A
    [J]. NATURE, 1992, 356 (6366) : 215 - 221
  • [3] FAIN PR, 1992, CYTOGENET CELL GENET, V60, P178
  • [4] P53 - A GLIMPSE AT THE PUPPET BEHIND THE SHADOW PLAY
    FRIEND, S
    [J]. SCIENCE, 1994, 265 (5170) : 334 - 335
  • [5] GREENBLATT MS, 1994, CANCER RES, V54, P4855
  • [6] MOLECULAR-CLONING AND INVITRO EXPRESSION OF A CDNA CLONE FOR HUMAN CELLULAR TUMOR-ANTIGEN P53
    HARLOW, E
    WILLIAMSON, NM
    RALSTON, R
    HELFMAN, DM
    ADAMS, TE
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1985, 5 (07) : 1601 - 1610
  • [7] RETINOBLASTOMA - FOR OUR EYES ONLY
    HARLOW, E
    [J]. NATURE, 1992, 359 (6393) : 270 - 271
  • [8] GENETICS AND CYTOGENETICS OF RETINOBLASTOMA
    HORSTHEMKE, B
    [J]. CANCER GENETICS AND CYTOGENETICS, 1992, 63 (01) : 1 - 7
  • [9] A TP53 MUTATION DETECTED IN CELLS ESTABLISHED FROM AN OSTEOSARCOMA, BUT NOT IN THE RETINOBLASTOMA OF A PATIENT WITH BILATERAL RETINOBLASTOMA AND MULTIPLE PRIMARY OSTEOSARCOMAS
    HOVIG, E
    ANDREASSEN, A
    FANGAN, BM
    BORRESEN, AL
    [J]. CANCER GENETICS AND CYTOGENETICS, 1992, 64 (02) : 178 - 182
  • [10] APOPTOSIS OR RETINOBLASTOMA - ALTERNATIVE FATES OF PHOTORECEPTORS EXPRESSING THE HPV-16 E7 GENE IN THE PRESENCE OR ABSENCE OF P53
    HOWES, KA
    RANSOM, LN
    PAPERMASTER, DS
    LASUDRY, JGH
    ALBERT, DM
    WINDLE, JJ
    [J]. GENES & DEVELOPMENT, 1994, 8 (11) : 1300 - 1310