Physical performance is associated with markers of vascular inflammation in patients with coronary heart disease

被引:45
作者
Schumacher, Anita
Peersen, Kari
Sommervoll, Lisbeth
Seljeflot, Ingebjorg
Arnesen, Harald
Otterstad, Jan Erik
机构
[1] Hosp Vestfold, Dept Med, Div Cardiol, N-3103 Tonsberg, Norway
[2] Hosp Vestfold, Dept Microbiol, N-3103 Tonsberg, Norway
[3] Ullevaal Univ Hosp, Cardiovasc Res Ctr, Oslo, Norway
来源
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2006年 / 13卷 / 03期
关键词
cardiac rehabilitation; soluble cell adhesion molecules; physical performance; C reactive protein; interleukin; 6; tumor necrosis factor;
D O I
10.1097/00149831-200606000-00010
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Coronary heart disease as well as major cardiovascular risk factors are associated with elevated levels of pro-inflammatory markers. There is, however, limited information about how changes in lifestyle improving the cardiovascular risk profile influence these levels. The aim of the study was to evaluate whether changes in lifestyle measures with special attention to physical activity, were associated with the levels of such markers. Design Coronary heart disease patients (n=197) were randomized to either a comprehensive lifestyle intervention programme comprising regular physical activity, low fat diet and smoking cessation, or usual care with routine follow-up in the outpatient clinic for 6 months. An exercise test and fasting blood samples analysed for soluble cell adhesion molecules, C reactive protein and pro-inflammatory cytokines were evaluated before and at the end of the study. Results Improved diet, physical performance and reduction in smoking were obtained in the intervention programme when compared with usual care patients, but no significant group differences in levels of inflammatory markers were observed. In the total population, however, physical performance significantly and inversely predicted levels of soluble cell adhesion molecule 1, (P < 0.001), C-reactive protein (P < 0.001) and interleukin-6 (P=0.01) at 6 months. Smokers had elevated levels of soluble cell adhesion molecule 1 when compared with non-smokers (P= 0.011). Conclusions We demonstrated that physical performance is inversely correlated with levels of pro-inflammatory markers in coronary heart disease patients, possibly retarding the process of atherosclerosis. No effect on inflammatory markers was obtained with a 6-month lifestyle intervention programme when compared with patients who received usual care follow-up.
引用
收藏
页码:356 / 362
页数:7
相关论文
共 44 条
[1]   C-reactive protein and coronary artery disease:: Additional evidence of the implication of an inflammatory process in acute coronary syndromes [J].
Abdelmouttaleb, I ;
Danchin, N ;
Ilardo, C ;
Aimone-Gastin, I ;
Angioï, M ;
Lozniewski, A ;
Loubinoux, J ;
Le Faou, A ;
Guéant, JL .
AMERICAN HEART JOURNAL, 1999, 137 (02) :346-351
[2]  
Andersen LF, 1999, AM J EPIDEMIOL, V150, P75, DOI 10.1093/oxfordjournals.aje.a009921
[3]   Vascular adhesion molecule-1 and markers of platelet function before and after a treatment with iloprost or a supervised physical exercise program in patients with peripheral arterial disease [J].
Arosio, E ;
Minuz, P ;
Prior, M ;
Zuliani, V ;
Gaino, S ;
De Marchi, S ;
Fontana, L ;
Andrioli, G ;
Lechi, C ;
Lechi, A .
LIFE SCIENCES, 2001, 69 (04) :421-433
[4]  
BEVILACQUA MP, 1993, ANNU REV IMMUNOL, V11, P767, DOI 10.1146/annurev.iy.11.040193.004003
[5]  
Blann AD, 1998, THROMB HAEMOSTASIS, V79, P1080
[6]   Circulating endothelial cell leucocyte adhesion molecules in ischaemic heart disease [J].
Blann, AD ;
Amiral, J ;
McCollum, CN .
BRITISH JOURNAL OF HAEMATOLOGY, 1996, 95 (02) :263-265
[7]  
BLANN AD, 1994, THROMB HAEMOSTASIS, V72, P151
[8]  
BORG G, 1970, Scandinavian Journal of Rehabilitation Medicine, V2, P92
[9]  
CAMPBELL NC, 2003, BRIT MED J, V316, P1424
[10]   Exercise training enhances endothelial function in young men [J].
Clarkson, P ;
Montgomery, HE ;
Mullen, MJ ;
Donald, AE ;
Powe, AJ ;
Bull, T ;
Jubb, M ;
World, M ;
Deanfield, JE .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (05) :1379-1385