Two novel alleles HLA-A*02:433 and HLA-A*02:434 identified in Saudi bone marrow donors using sequence-based typing

被引：3
|
作者：
Fakhoury, H. A. [1 ]
Jawdat, D. [2 ]
Alaskar, A. S. [2 ]
Al Jumah, M. [2 ]
Cereb, N. [3 ]
Hajeer, A. H. [4 ,5 ]
机构：
[1] King Saud bin Abdulaziz Univ Hlth Sci, Coll Sci & Hlth Profess, Dept Basic Sci, Natl Guard Hlth Affairs, Riyadh, Saudi Arabia
[2] Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia
[3] Histogenetics, New York, NY USA
[4] King Saud bin Abdulaziz Univ Hlth Sci, Coll Med, Dept Basic Med Sci, Natl Guard Hlth Affairs, Riyadh, Saudi Arabia
[5] Natl Guard Hlth Affairs, King Abdullah Int Med Res Ctr, Saudi Stem Cell Donor Registry, Riyadh, Saudi Arabia
来源：
INTERNATIONAL JOURNAL OF IMMUNOGENETICS | 2014年 / 41卷 / 04期
关键词：
HLA SYSTEM; NOMENCLATURE;
D O I：
10.1111/iji.12131
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In this report, we present two novel HLA-A alleles: HLA-A*02:433 and HLA-A*02:434. These alleles were identified by sequence-based typing method (SBT), in two donors for the Saudi Bone Marrow Donor Registry (SBMDR). Allele A*02:433 is identical to A*02:05:01G except for a G to A substitution at nucleotide position 449 in exon 2. This substitution results in glycine to serine substitution at position 83. Whereas, allele A*02:434 is identical to A*02:01:01G except for a C to A substitution at nucleotide position 245 in exon 2, which results in phenylalanine to threonine substitution at position 15. The generation of both alleles appears to be the result of nucleotide point mutation involving 02:01:01 and 02:05:01.
引用
收藏
页码：338 / 339
页数：2
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