A network-based method for mechanistic investigation of Shexiang Baoxin Pill's treatment of cardiovascular diseases

被引：88
作者：
Fang, Hai-Yang [1 ]
Zeng, Hua-Wu [2 ]
Lin, Li-Mei [1 ]
Chen, Xing [1 ]
Shen, Xiao-Na [1 ]
Fu, Peng [2 ]
Lv, Chao [2 ]
Liu, Qun [2 ]
Liu, Run-Hui [1 ,2 ]
Zhang, Wei-Dong [2 ]
Zhao, Jing [1 ,2 ]
机构：
[1] Logist Engn Univ, Dept Math, Chongqing, Peoples R China
[2] Second Mil Med Univ, Dept Nat Med Chem, Shanghai, Peoples R China
来源：
SCIENTIFIC REPORTS | 2017年 / 7卷
基金：
中国国家自然科学基金;
关键词：
CHINESE MEDICINE FORMULA; CONNECTIVITY MAP; MYOCARDIAL-INFARCTION; RAT PLASMA; E-SELECTIN; RECEPTOR; PHARMACOKINETICS; POLYMORPHISMS; METABOLITES; EXPRESSION;
D O I：
10.1038/srep43632
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Shexiang Baoxin Pill (SBP), a traditional Chinese medicine formula, is commonly used to treat cardiovascular disease (CVD) in China. However, the complexity of composition and targets has deterred our understanding of its mechanism of action. Using network pharmacology-based approaches, we established the mechanism of action for SBP to treat CVD by analyzing protein-protein interactions and pathways. The computational results were confirmed at the gene expression level in microarray-based studies. Two of the SBP's targets were further confirmed at the protein level by Western blot. In addition, we validated the theory that SBP's plasma absorbed compounds play major therapeutic role in treating CVD.
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页数：11
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