Lab-on-Chip for testing myelotoxic effect of drugs and chemicals

被引：5

作者：

Rasponi, Marco ^{[1
]}

Gazaneo, Andrea ^{[1
]}

Bonomi, Arianna ^{[2
]}

Ghiglietti, Andrea ^{[3
]}

Occhetta, Paola ^{[1
]}

Fiore, Gianfranco Beniamino ^{[1
]}

Pessina, Augusto ^{[2
]}

Redaelli, Alberto ^{[1
]}

机构：

[1] Politecn Milan, Dept Elect Informat & Bioengn, I-20133 Milan, Italy

[2] Univ Milan, Dept Biomed Surg & Dent Sci, I-20133 Milan, Italy

[3] Politecn Milan, Dept Math Francesco Brioschi, I-20133 Milan, Italy

来源：

MICROFLUIDICS AND NANOFLUIDICS | 2015年 / 19卷 / 04期

关键词：

Lab-on-Chip; Microfluidics; Clonogenic test; CFU-GM; CB-MNC; CFU-GM; DEVICE; ASSAY;

D O I：

10.1007/s10404-015-1622-0

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In the last 20 years, one of the main goals in the drug discovery field has been the development of reliable in vitro models. In particular, in 2006 the European Centre for the Validation of Alternative Methods has approved the colony-forming unit granulocytes-macrophages test, which is the first and currently unique test applied to evaluate the myelotoxicity of xenobiotics in vitro. The present work aimed at miniaturizing this in vitro assay by developing and validating a Lab-on-Chip platform consisting of a high number of bioreactor chambers with screening capabilities in a high-throughput regime.

引用

页码：935 / 940

页数：6

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