The role of plasma gelsolin in cardiopulmonary bypass induced acute lung injury in infants and young children: a pilot study

被引:10
作者
Shi, ShanShan [1 ]
Chen, Chi [2 ,3 ]
Zhao, DongYan [2 ,3 ]
Liu, XiWang [2 ,3 ]
Cheng, Baoli [4 ]
Wu, ShuiJing [4 ]
Lin, Ru [2 ,3 ]
Tan, LinHua [1 ]
Fang, XiangMing [4 ]
Shu, Qiang [2 ,3 ]
机构
[1] Zhejiang Univ, Childrens Hosp, Coll Med, Surg Intens Care Unit, Hangzhou 310003, Zhejiang, Peoples R China
[2] Zhejiang Univ, Childrens Hosp, Coll Med, Dept Thorac & Cardiovasc Surg, Hangzhou 310003, Zhejiang, Peoples R China
[3] Zhejiang Key Lab Diag & Therapy Neonatal Dis, Hangzhou 310003, Zhejiang, Peoples R China
[4] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Anesthesiol, Hangzhou 310003, Zhejiang, Peoples R China
来源
BMC ANESTHESIOLOGY | 2014年 / 14卷
基金
中国国家自然科学基金;
关键词
Plasma gelsolin; Acute lung injury; Cardiac surgery; Cardiopulmonary bypass; Infant; Young children; Congenital heart disease; PROLONGED MECHANICAL VENTILATION; CARDIAC-SURGERY; TRANSFUSION; PREDICTION; COMPLICATIONS; OUTCOMES; DISEASE; ACID;
D O I
10.1186/1471-2253-14-67
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background: Acute lung injury (ALI) induced by cardiopulmonary bypass (CPB, CPB-ALI) is a common and serious complication after cardiac surgery. And infants and young children are more prone to CPB-ALI. The purpose of this study was to investigate the perioperative changes of plasma gelsolin (pGSN) in patients below 3years of age with cardiac surgeries and CPB, and determine whether pGSN are associated with the occurrence and severity of CPB-ALI. Methods: Seventy-seven consecutive patients <= 3 years of age with congenital heart diseases (CHD) performed on open heart surgery with CPB were finally enrolled, and assigned to ALI and non-ALI groups according to the American-European Consensus Criteria. Plasma concentrations of gelsolin and total protein were measured at following 8 time points: before CPB (a), after CPB (b), 2 hours after CPB (c), 6 hours after CPB (d), 12 hours after CPB (e), 24 hours after CPB (f), 48 hours after CPB (g) and 72 hours after CPB (h). Results: Twenty-seven (35.1%) patients developed CPB-ALI in the study, including eleven (14.3%) patients with ARDS. The earliest significant drop of pGSN and normalized pGSN (pGSN(N)) of ALI group both occurred at 6 hours after CPB (p = 0.04 and p < 0.01), which was much earlier than those of non-ALI group (48 hours, p = 0.03 and 24 hours, p < 0.01); PGSN of ALI group before CPB and 6 hours after CPB were both significantly lower than those of non-ALI group (p < 0.01); PGSN(N) of ALI group before CPB and 6 hours after CPB were both significantly lower than those of non-ALI group (p < 0.01, p = 0.04); PGSN before CPB was the only independent risk factor predicting the occurrence of CPB-ALI (OR, 1.023; 95% CI, 1.007-1.039; p < 0.01) with an AUC of 0.753 (95% CI, 0.626-0.880); The optimal cutoff value of pGSN before CPB was 264.2 mg/ L, with a sensitivity of 58.3% and a specificity 94.7%. And lower pGSN before CPB was significantly associated with the severity of CS-AKI (r = -0.45, p < 0.01). Conclusions: Patients developing CPB-ALI had lower plasma gelsolin reservoir and a much more amount and rapid consumption of plasma gelsolin early after operation. PGSN before CPB was an early and sensitive predictor of CPB-ALI in infants and young children undergoing cardiac surgery, and was negatively correlated with the severity of CPB-ALI.
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