Adverse effects of methotrexate in three psoriatic arthritis patients

被引：8

作者：

Maejima, Hideki ^{[1
]}

Watarai, Akira ^{[1
]}

Nakano, Toshiaki ^{[1
]}

Katayama, Chieko ^{[1
]}

Nishiyama, Hiromi ^{[1
]}

Katsuoka, Kensei ^{[1
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Dermatol, Sagamihara, Kanagawa 2520374, Japan

来源：

RHEUMATOLOGY INTERNATIONAL | 2014年 / 34卷 / 04期

关键词：

Psoriatic arthritis; Pulmonary tuberculosis; Viral uveitis; Renal cell carcinoma; Methotrexate; LOW-DOSE METHOTREXATE; RHEUMATOID-ARTHRITIS; THERAPY; REACTIVATION; VIRUS; DRUGS;

D O I：

10.1007/s00296-012-2649-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Methotrexate, a folic acid analogue with anti-proliferative and anti-inflammatory effects, is commonly used to treat patients with severe destructive psoriatic arthritis and has considerable efficacy. Combined anti-tumor necrosis factor and MTX therapy result in less treatment discontinuation due to adverse events. Despite its efficacy, MTX may result in adverse effects including hepatic, pulmonary, and renal toxicity as well as lymphoproliferative disorders and predisposition to infection. We herein report rare adverse effects of MTX treatment, specifically asymptomatic pulmonary tuberculosis, renal cell carcinoma, and lateral uveitis, in three psoriatic arthritis patients treated with MTX. MTX is an important drug for the treatment for psoriatic arthritis patient, but an awareness of the possible adverse effects is needed.

引用

页码：571 / 574

页数：4

共 16 条

[1] The diagnosis and treatment of early psoriatic arthritis [J].

Anandarajah, Allen P. ;

Ritchlin, Christopher T. .

NATURE REVIEWS RHEUMATOLOGY, 2009, 5 (11) :634-641

[2]

Belzunegui J, 2001, CLIN EXP RHEUMATOL, V19, P727

[3] Late reactivation of spinal tuberculosis by low-dose methotrexate therapy in a patient with rheumatoid arthritis [J].

Binymin, K ;

Cooper, RG .

RHEUMATOLOGY, 2001, 40 (03) :341-342

[4] Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin [J].

Clarke, Loren E. ;

Junkins-Hopkins, Jacqueline ;

Seykora, John T. ;

Adler, Donald J. ;

Elenitsas, Rosalie .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 56 (04) :686-690

[5] The mechanism of action of methotrexate [J].

Cronstein, BN .

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA, 1997, 23 (04) :739-+

[6] Treatment of Very Early Rheumatoid Arthritis With Symptomatic Therapy, Disease-Modifying Antirheumatic Drugs, or Biologic Agents A Cost-Effectiveness Analysis [J].

Finckh, Axel ;

Bansback, Nick ;

Marra, Carlo A. ;

Anis, Aslam H. ;

Michaud, Kaleb ;

Lubin, Stanley ;

White, Marc ;

Sizto, Sonia ;

Liang, Matthew H. .

ANNALS OF INTERNAL MEDICINE, 2009, 151 (09) :612-W198

[7]

Gwak GY, 2007, CLIN EXP RHEUMATOL, V25, P888

[8] How early should psoriatic arthritis be treated with a TNF-blocker? [J].

Harty, Leonard ;

Veale, Douglas James .

CURRENT OPINION IN RHEUMATOLOGY, 2010, 22 (04) :393-396

[9]

Helliwell PS, 2008, J RHEUMATOL, V35, P472

[10] Viral anterior uveitis [J].

Jap, Aliza ;

Chee, Soon-Phaik .

CURRENT OPINION IN OPHTHALMOLOGY, 2011, 22 (06) :483-488

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