When transfer-messenger RNA scars reveal its ancient origins

被引：2

作者：

Guyomar, Charlotte ^{[1
]}

Gillet, Reynald ^{[1
]}

机构：

[1] Univ Rennes, CNRS, IGDR, UMR 6290, F-35000 Rennes, France

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2019年 / 1447卷 / 01期

关键词：

alanine; genetic code; RNA world; tmRNA; trans-translation; 2-PIECE TMRNA; AMINO-ACIDS; COMPLEX; CODON; LIFE;

D O I：

10.1111/nyas.14035

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In bacteria, trans-translation is the primary quality control mechanism for rescuing ribosomes arrested during translation. This key process is universally conserved and plays a crucial role in the viability and virulence of all bacteria. It is performed by transfer-messenger RNA (tmRNA) and its protein partner small protein B (SmpB). Here, we show that tmRNA is a key molecule that could have given birth to modern protein synthesis. The traces of an ancient RNA world persist in the structure of modern tmRNA, suggesting its old origins. Therefore, since it has both tRNA and mRNA functions, tmRNA could be the missing link that allowed modern genetic code to be read by the ribosome.

引用

页码：80 / 87

页数：8

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