Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO

被引：158
作者：
Kim, Na Yeun [1 ]
Cheon, Cheol-Hong [1 ]
机构：
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 15期
基金：
新加坡国家研究基金会;
关键词：
Quinazolinones; Aerobic oxidation; DMSO; Anthranilamide; One-pot synthesis; ONE-POT CONVERSION; EFFICIENT; DERIVATIVES; CATALYST; RECEPTOR; BENIGN; DESIGN;
D O I：
10.1016/j.tetlet.2014.02.065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly environmentally benign protocol for the synthesis of quinazolinones from anthranilamides and aldehydes via aerobic oxidation was developed in wet DMSO. This protocol is operationally simple, exhibits broad substrate scope, and does not need toxic metal catalysts and bases. In addition, the utility of this transformation was further demonstrated by converting the resulting quinazolinones into other useful products in the same-pot without their isolation. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2340 / 2344
页数：5
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