Fatty Pancreas, Insulin Resistance, and β-Cell Function: A Population Study Using Fat-Water Magnetic Resonance Imaging

被引:205
作者
Wong, Vincent Wai-Sun [1 ,2 ]
Wong, Grace Lai-Hung [1 ,2 ]
Yeung, David Ka-Wai [3 ]
Abrigo, Jill M. [4 ]
Kong, Alice Pik-Shan [2 ]
Chan, Ruth Suk-Mei [2 ,5 ]
Chim, Angel Mei-Ling [1 ,2 ]
Shen, Jiayun [1 ,2 ]
Ho, Chung-Shun [6 ]
Woo, Jean [2 ,5 ]
Chu, Winnie Chiu-Wing [1 ,4 ]
Chan, Henry Lik-Yuen [1 ,2 ]
机构
[1] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Dept Clin Oncol, Hong Kong, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Hong Kong, Hong Kong, Peoples R China
[5] Chinese Univ Hong Kong, Ctr Nutr Studies, Hong Kong, Hong Kong, Peoples R China
[6] Chinese Univ Hong Kong, Dept Chem Pathol, Hong Kong, Hong Kong, Peoples R China
关键词
LIVER-DISEASE; RISK-FACTORS; METABOLIC SYNDROME; ADVANCED FIBROSIS; NATURAL-HISTORY; PREVALENCE; STEATOSIS; CHINESE; QUANTIFICATION; SUSCEPTIBILITY;
D O I
10.1038/ajg.2014.1
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
OBJECTIVES: Nonalcoholic fatty liver disease is the most common chronic liver disease. Fatty pancreas has also been described but is difficult to assess. It is now possible to measure pancreatic and liver fat accurately with magnetic resonance imaging (MRI). We aimed to define the normal range of pancreatic fat and identify factors associated with fatty pancreas. In addition, the effect of fatty liver and fatty pancreas on insulin resistance (IR) and pancreatic beta-cell function was studied. METHODS: Fat-water MRI and proton-magnetic resonance spectroscopy were performed on 685 healthy volunteers from the general population to measure pancreatic and liver fat, respectively. On the basis of fasting plasma glucose and insulin levels, the IR and beta-cell function were assessed using the homeostasis model assessment (HOMA). RESULTS: Among subjects without significant alcohol consumption or any component of metabolic syndrome, 90% had pancreatic fat between 1.8 and 10.4%. Using the upper limit of normal of 10.4%, 110 (16.1%; 95% confidence interval 13.3-18.8%) subjects had fatty pancreas. On multivariable analysis, high serum ferritin, central obesity, and hypertriglyceridemia were independent factors associated with fatty pancreas. Subjects with both fatty pancreas and fatty liver had higher HOMA-IR than did those with either condition alone. Fatty pancreas was not associated with HOMA-beta after adjusting for liver fat and body mass index. CONCLUSIONS: In all, 16.1% of this community cohort of adult Hong Kong Chinese volunteers had a fatty pancreas by our definition. Central obesity, hypertriglyceridemia, and hyperferritinemia are associated with fatty pancreas. Individuals with fatty pancreas have increased IR.
引用
收藏
页码:589 / 597
页数:9
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