Chemical exchange saturation transfer MRI using intermolecular double-quantum coherences with multiple refocusing pulses

被引:3
作者
Lu, Jianhua [1 ]
Cai, Congbo [2 ]
Cai, Shuhui [1 ]
Chen, Zhong [1 ]
Zhou, Jinyuan [3 ]
机构
[1] Xiamen Univ, Dept Elect Sci, Fujian Prov Key Lab Plasma & Magnet Resonance, Xiamen 361005, Peoples R China
[2] Xiamen Univ, Dept Commun Engn, Xiamen 361005, Peoples R China
[3] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA
基金
美国国家卫生研究院; 中国国家自然科学基金;
关键词
CEST; MRI; Intermolecular double-quantum coherence; Image contrast; Nuclear Overhauser enhancement; DIPOLAR FIELD; IN-VIVO; HUMAN BRAIN; 7; T; INHOMOGENEOUS FIELDS; SIGNAL ENHANCEMENT; CONTRAST AGENTS; TRANSFER CEST; SOLUTION NMR; RELAXATION;
D O I
10.1016/j.mri.2014.03.001
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Chemical exchange saturation transfer (CEST) provides a new type of image contrast in MRI. Due to the intrinsically low CEST effect, new and improved experimental techniques are required to achieve reliable and quantitative CEST images. In the present work, we proposed a novel and more sensitive CEST acquisition approach, based on the intermolecular double-quantum coherence with a module of multiple refocusing pulses (iDQC-MRP). Experiments were performed on creatine and egg white phantoms using a Varian 7 T animal MRI scanner. The iDQC-MRP CEST technique showed a substantial enhancement in CEST and nuclear Overhauser enhancement (NOE) signal intensities, compared to the standard single-quantum coherence approach. In addition, the iDQC-MRP approach increased the signal-to-noise ratio of acquired saturation images, compared to the conventional iDQC approach. The new iDQC-MRP CEST sequence provides a promising way for exploiting in vivo CEST and NOE imaging applications. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:759 / 765
页数:7
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