Effects of Bisphosphonate on Oxidative Stress Levels in Patients With Different Types of Cancer

被引：9

作者：

Kocer, Murat ^{[1
]}

Naziroglu, Mustafa ^{[2
]}

Kocer, Gulperi ^{[3
,4
]}

Soenmez, Tolga Taha ^{[5
]}

机构：

[1] Suleyman Demirel Univ, Fac Med, Dept Med Oncol, TR-32200 Isparta, Turkey

[2] Suleyman Demirel Univ, Neurosci Res Ctr, TR-32200 Isparta, Turkey

[3] Suleyman Demirel Univ, Fac Dent, Dept Oral Surg, TR-32200 Isparta, Turkey

[4] Suleyman Demirel Univ, Fac Dent, Dept Maxillofacial Surg, TR-32200 Isparta, Turkey

[5] Rhein Westfal TH Aachen, Dept Oral & Maxillofacial Surg, Fac Med, Aachen, Germany

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 02期

关键词：

Bisphosphonate; Calcium; Cancer; Glutathione peroxidase; Oxidative stress; Vitamin E; ALPHA-TOCOPHEROL; INFLAMMATORY RESPONSE; SELENIUM; RETINOL; CHEMOTHERAPY; ANTIOXIDANTS; COMBINATION; GROWTH; BLOOD;

D O I：

10.3109/07357907.2013.861475

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the effects of bisphosphonate (BP) on oxidative stress levels in blood of patients with cancer. In total, 19 patients with cancer and 21 healthy subjects were included in the study. BP was intravenously administrated to the participants for 6 weeks. The patients had higher lipid peroxidation (LP) levels in the plasma and erythrocyte samples but lower glutathione peroxidase (GSH-Px) and plasma vitamin E values. In patients treated with BP, calcium and LP levels decreased, but GSH-Px and vitamin E values improved. In conclusion, we observed that treatment with BP alleviated oxidative stress induced by cancer.

引用

页码：37 / 42

页数：6

共 32 条

[11] Effects of vitamin E supplementation on blood antioxidants levels in patients with Behcet's disease [J].

Kökçam, I ;

Naziroglu, M .

CLINICAL BIOCHEMISTRY, 2002, 35 (08) :633-639

[12] Colchicine Modulates Oxidative Stress in Serum and Neutrophil of Patients with Behcet Disease Through Regulation of Ca2+ Release and Antioxidant System [J].

Korkmaz, Selma ;

Erturan, Ijlal ;

Naziroglu, Mustafa ;

Uguz, Abdulhadi Cihangir ;

Cig, Bilal ;

Ovey, Ishak Suat .

JOURNAL OF MEMBRANE BIOLOGY, 2011, 244 (03) :113-120

[13] Zoledronate and pamidronate depress neutrophil functions and survival in mice [J].

Kuiper, J. W. P. ;

Forster, C. ;

Sun, C. ;

Peel, S. ;

Glogauer, M. .

BRITISH JOURNAL OF PHARMACOLOGY, 2012, 165 (02) :532-539

[14]

Laurent A, 2005, CANCER RES, V65, P948

[15] GLUTATHIONE PEROXIDASE-ACTIVITY IN SELENIUM-DEFICIENT RAT-LIVER [J].

LAWRENCE, RA ;

BURK, RF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 71 (04) :952-958

[16]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[17]

Melichar B, 2007, ANTICANCER RES, V27, P4397

[18] Serum Retinol, Alpha-Tocopherol and Systemic Inflammatory Response in Metastatic Colorectal Carcinoma Patients Treated with Combination Chemotherapy and Cetuximab [J].

Melichar, Bohuslav ;

Krcmova, Lenka ;

Kalabova, Hana ;

Holeckova, Petra ;

Kasparova, Marketa ;

Plisek, Jiri ;

Hyspler, Radomir ;

Studentova, Hana ;

Solichova, Dagmar .

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 2010, 56 (04) :222-226

[19]

Melichar B, 2009, ANTICANCER RES, V29, P4813

[20] NEUROPROTECTION INDUCED BY N-ACETYLCYSTEINE AGAINST CYTOSOLIC GLUTATHIONE DEPLETION-INDUCED CA2+ INFLUX IN DORSAL ROOT GANGLION NEURONS OF MICE: ROLE OF TRPV1 CHANNELS [J].

Naziroglu, M. ;

Cig, B. ;

Ozgul, C. .

NEUROSCIENCE, 2013, 242 :151-160

← 1 2 3 4 →