Effects of Bisphosphonate on Oxidative Stress Levels in Patients With Different Types of Cancer

被引：9
作者：
Kocer, Murat [1 ]
Naziroglu, Mustafa [2 ]
Kocer, Gulperi [3 ,4 ]
Soenmez, Tolga Taha [5 ]
机构：
[1] Suleyman Demirel Univ, Fac Med, Dept Med Oncol, TR-32200 Isparta, Turkey
[2] Suleyman Demirel Univ, Neurosci Res Ctr, TR-32200 Isparta, Turkey
[3] Suleyman Demirel Univ, Fac Dent, Dept Oral Surg, TR-32200 Isparta, Turkey
[4] Suleyman Demirel Univ, Fac Dent, Dept Maxillofacial Surg, TR-32200 Isparta, Turkey
[5] Rhein Westfal TH Aachen, Dept Oral & Maxillofacial Surg, Fac Med, Aachen, Germany
来源：
CANCER INVESTIGATION | 2014年 / 32卷 / 02期
关键词：
Bisphosphonate; Calcium; Cancer; Glutathione peroxidase; Oxidative stress; Vitamin E; ALPHA-TOCOPHEROL; INFLAMMATORY RESPONSE; SELENIUM; RETINOL; CHEMOTHERAPY; ANTIOXIDANTS; COMBINATION; GROWTH; BLOOD;
D O I：
10.3109/07357907.2013.861475
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the effects of bisphosphonate (BP) on oxidative stress levels in blood of patients with cancer. In total, 19 patients with cancer and 21 healthy subjects were included in the study. BP was intravenously administrated to the participants for 6 weeks. The patients had higher lipid peroxidation (LP) levels in the plasma and erythrocyte samples but lower glutathione peroxidase (GSH-Px) and plasma vitamin E values. In patients treated with BP, calcium and LP levels decreased, but GSH-Px and vitamin E values improved. In conclusion, we observed that treatment with BP alleviated oxidative stress induced by cancer.
引用
收藏
页码：37 / 42
页数：6
相关论文
共 50 条
  • [1] Effects of 5-Fluorouracil on Oxidative Stress and Calcium Levels in the Blood of Patients with Newly Diagnosed Colorectal Cancer
    Kocer, Murat
    Naziroglu, Mustafa
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2013, 155 (03) : 327 - 332
  • [2] Association between oxidative stress and selenium levels in patients with breast cancer at different clinical stages
    Sancak, B
    Ünal, A
    Candan, S
    Coskun, U
    Günel, N
    JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE, 2003, 16 (2-3) : 87 - 94
  • [3] Combined Effects of Cyclic Heat Stress, Dietary Induced Oxidative Stress and Different Levels of Antioxidant on Gut Fermentation Activity and Mucosal Morphology in Broiler Chickens
    Rezar, Vida
    Pal, Manca Pecjak
    Leskovec, Jakob
    Levart, Alenka
    Salobir, Janez
    Lavrencic, Andrej
    Vrecl, Milka
    Pirman, Tatjana
    AGRICULTURE-BASEL, 2024, 14 (01):
  • [4] Oxidative stress in patients with cancer: two sides of the same coin
    Vinas, Gemma
    Puig, Teresa
    Porta, Rut
    MEDICINA CLINICA, 2012, 139 (04): : 171 - 175
  • [5] The relationship between HLA-G levels and oxidative stress parameters in patients with breast cancer
    Bozalioglu, Sema
    Kilic, Nedret
    Yildirim, Zuhal
    Basturk, Bilkay
    Kurukahvecioglu, Osman
    TURKISH JOURNAL OF MEDICAL SCIENCES, 2013, 43 (06) : 870 - 877
  • [6] Tissue levels of oxidative stress markers and antioxidants in colorectal cancer patients
    Burwaiss, Abdullah
    Ammar, Manal
    Alghazeer, Rabia
    Eljamil, Ashour
    Alarbie, Dalal
    Elghmasi, Sana
    Al-Griw, Mohamed
    Alansari, Wafa S.
    Shamlan, Ghalia
    Eskandrani, Areej A.
    MAIN GROUP CHEMISTRY, 2022, 21 (02) : 491 - 499
  • [7] Biomarkers of oxidative stress and smoking in cancer patients
    Burlakova, Elena B.
    Zhizhina, Galina P.
    Gurevich, Svetlana M.
    Fatkullina, Lyudmila D.
    Kozachenko, Antonina I.
    Nagler, Lena G.
    Zavarykina, Tatiana M.
    Kashcheev, Viktor V.
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2010, 6 (01) : 47 - 53
  • [8] Cisplatin Combination Chemotherapy Induces Oxidative Stress in Advance Non Small Cell Lung Cancer Patients
    Srivastava, Anand Narain
    Gupta, Abhilasha
    Srivastava, Shruti
    Natu, S. M.
    Mittal, Balraj
    Negi, M. P. S.
    Prasad, Rajendra
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2010, 11 (02) : 465 - 471
  • [9] Effect of Zinc Supplementation on Antioxidant Defenses and Oxidative Stress Markers in Patients Undergoing Chemotherapy for Colorectal Cancer: a Placebo-Controlled, Prospective Randomized Trial
    de Figueiredo Ribeiro, Sofia Miranda
    Moreno Braga, Camila Bitu
    Peria, Fernanda Maris
    Domenici, Fernanda Aparecida
    Martinez, Edson Zangiacomi
    Feres, Omar
    Ribeiro da Rocha, Jose Joaquim
    de Carvalho da Cunha, Selma Freire
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2016, 169 (01) : 8 - 16
  • [10] Effects of 5-Fluorouracil on Oxidative Stress and Calcium Levels in the Blood of Patients with Newly Diagnosed Colorectal Cancer
    Murat Koçer
    Mustafa Nazıroğlu
    Biological Trace Element Research, 2013, 155 : 327 - 332
12345