Effects of Bisphosphonate on Oxidative Stress Levels in Patients With Different Types of Cancer

被引：9
作者：
Kocer, Murat [1 ]
Naziroglu, Mustafa [2 ]
Kocer, Gulperi [3 ,4 ]
Soenmez, Tolga Taha [5 ]
机构：
[1] Suleyman Demirel Univ, Fac Med, Dept Med Oncol, TR-32200 Isparta, Turkey
[2] Suleyman Demirel Univ, Neurosci Res Ctr, TR-32200 Isparta, Turkey
[3] Suleyman Demirel Univ, Fac Dent, Dept Oral Surg, TR-32200 Isparta, Turkey
[4] Suleyman Demirel Univ, Fac Dent, Dept Maxillofacial Surg, TR-32200 Isparta, Turkey
[5] Rhein Westfal TH Aachen, Dept Oral & Maxillofacial Surg, Fac Med, Aachen, Germany
来源：
CANCER INVESTIGATION | 2014年 / 32卷 / 02期
关键词：
Bisphosphonate; Calcium; Cancer; Glutathione peroxidase; Oxidative stress; Vitamin E; ALPHA-TOCOPHEROL; INFLAMMATORY RESPONSE; SELENIUM; RETINOL; CHEMOTHERAPY; ANTIOXIDANTS; COMBINATION; GROWTH; BLOOD;
D O I：
10.3109/07357907.2013.861475
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the effects of bisphosphonate (BP) on oxidative stress levels in blood of patients with cancer. In total, 19 patients with cancer and 21 healthy subjects were included in the study. BP was intravenously administrated to the participants for 6 weeks. The patients had higher lipid peroxidation (LP) levels in the plasma and erythrocyte samples but lower glutathione peroxidase (GSH-Px) and plasma vitamin E values. In patients treated with BP, calcium and LP levels decreased, but GSH-Px and vitamin E values improved. In conclusion, we observed that treatment with BP alleviated oxidative stress induced by cancer.
引用
收藏
页码：37 / 42
页数：6
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