From Upper Respiratory Symptoms to Hemophagocytic Lymphohistiocytosis: Case Report of a Human Adenovirus Infection in Haploidentical Hematopoietic Stem Cell Transplant Recipient

被引:1
|
作者
Demey, Baptiste [1 ,2 ]
Brault, Clement [3 ]
Maizel, Julien [3 ]
Francois, Catherine [1 ,2 ]
机构
[1] Amiens Univ, Dept Virol, Med Ctr, F-80000 Amiens, France
[2] Jules Verne Univ Picardie, AGIR Res Unit, EA 4294, F-80000 Amiens, France
[3] Amiens Univ, Intens Care Dept, Med Ctr, F-80000 Amiens, France
来源
PATHOGENS | 2021年 / 10卷 / 03期
关键词
adenovirus; hematopoietic stem cell transplant; lymphohistiocytosis; respiratory infection;
D O I
10.3390/pathogens10030340
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Human adenovirus infection is rare in adult population, except for in immunocompromised individuals. Recipients of allogenic haploidentical hematopoietic stem cell transplantation are reported at high risk for human adenovirus, which is often lethal when it evolves into the disseminated form. Despite existent guidelines, prevention, early diagnosis, and therapeutics remain challenging. Here, we report the case of a fatal evolution of human adenovirus respiratory infection and discuss the actual recommendations to prevent recurrence of this major issue.
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页数:5
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