Efficacy of Posaconazole in a Murine Disseminated Infection by Candida tropicalis

被引：6
|
作者：
Marine, Marcal [1 ]
Javier Pastor, F. [1 ]
Guarro, Josep [1 ]
机构：
[1] Univ Rovira & Virgili, IISPV, Unitat Microbiol, Fac Med & Ciencies Salut, E-43201 Reus, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 01期
关键词：
SUSCEPTIBILITIES; SURVEILLANCE; FLUCONAZOLE; ITRACONAZOLE; VORICONAZOLE;
D O I：
10.1128/AAC.01136-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluated the efficacy of posaconazole against Candida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by C. tropicalis.
引用
收藏
页码：530 / 532
页数：3
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