Comparison of Two Different Injection Rates of Gadoxetic Acid for Arterial Phase MRI of the Liver

被引:44
作者
Chung, Sang-Hoon [1 ,2 ]
Kim, Myeong-Jin [1 ,2 ,3 ,4 ]
Choi, Jin-Young [1 ,2 ]
Hong, Hye-Suk [1 ,2 ]
机构
[1] Yonsei Univ, Coll Med, Severance Hosp, Dept Radiol, Seoul, South Korea
[2] Yonsei Univ, Coll Med, Severance Hosp, Res Inst Radiol Sci, Seoul, South Korea
[3] Yonsei Univ, Coll Med, Inst Gastroenterol, Seoul, South Korea
[4] Yonsei Univ, Coll Med, Brain Korea Project 21, Seoul, South Korea
关键词
InjIection rate; Gadoxetic acid; Hepatic dynamic MR; hepatocellular carcinoma; contrast material; GD-EOB-DTPA; FOCAL NODULAR HYPERPLASIA; HISTOPATHOLOGIC FINDINGS; HEPATIC ENHANCEMENT; CLINICAL-EVALUATION; CONTRAST MATERIAL; SPIRAL CT; SAFETY; EFFICACY; LESIONS;
D O I
10.1002/jmri.22057
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To compare two different injection rates for gadoxetic acid-enhanced hepatic arterial phase images on hepatic dynamic MRI. Materials and Methods: Hepatic arterial phase images were obtained after art intravenous bolus injection of gadoxetic acid at a rate of 1 mL/second in 62 patients and 2 mL/second in 64 patients on a 3 Tesla MR scanner using a test-bolus injection method. The signal-to-noise ratios (SNR) of the liver, portal vein, hepatic vein, aorta, spleen and pancreas were measured. The contrast-to-noise ratio (CNR) of hypervascular hepatic tumors was calculated. Two radiologists independently scored items to evaluate image quality of hepatic arterial phase and detected hypervascular hepatocellular carcinoma (HCC). Results: The SNR of the aorta on the arterial phase images was significantly higher in the I mL/second group (235.43 +/- 82.59) than in the 2 mL/second group (190.94 +/- 96.90, P < 0.05). The SNRs of the liver, spleen and pancreas, the CNRs of hypervascular hepatic tumors, the detection rate of hypervascular HCC and subjective ratings for the optimal arterial enhancement were comparable between the two groups. Conclusion: Injection rates of 2 mL/second and I mL/second provided comparable image qualities on arterial phase images of hepatic dynamic MRI using gadoxetic acid.
引用
收藏
页码:365 / 372
页数:8
相关论文
共 22 条
[1]   Moderate versus high concentration of contrast material for aortic and hepatic enhancement and tumor-to-liver contrast at multi-detector row CT [J].
Awai, K ;
Inoue, M ;
Yagyu, Y ;
Watanabe, M ;
Sano, T ;
Nin, S ;
Koike, R ;
Nishimura, Y ;
Yamashita, Y .
RADIOLOGY, 2004, 233 (03) :682-688
[2]   Aortic and hepatic enhancement and tumor-to-liver contrast: Analysis of the effect of different concentrations of contrast material at multi-detector row helical CV [J].
Awai, K ;
Takada, K ;
Onishi, H ;
Hori, S .
RADIOLOGY, 2002, 224 (03) :757-763
[3]   Efficacy and safety of MR imaging with liver-specific contrast agent: US Multicenter Phase III study [J].
Bluemke, DA ;
Sahani, D ;
Amendola, M ;
Balzer, T ;
Breuer, J ;
Brown, JJ ;
Casalino, DD ;
Davis, PL ;
Francis, IR ;
Krinsky, G ;
Lee, FT ;
Lu, D ;
Paulson, EK ;
Schwartz, LH ;
Siegelman, ES .
RADIOLOGY, 2005, 237 (01) :89-98
[4]   CONTRAST-ENHANCED NMR IMAGING - ANIMAL STUDIES USING GADOLINIUM-DTPA COMPLEX [J].
BRASCH, RC ;
WEINMANN, HJ ;
WESBEY, GE .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1984, 142 (03) :625-630
[5]   RANDOMIZED DOUBLE-BLIND TRIAL OF THE SAFETY AND EFFICACY OF 2 GADOLINIUM COMPLEXES (GD-DTPA AND GD-DOTA) [J].
BRUGIERES, P ;
GASTON, A ;
DEGRYSE, HR ;
PARIZEL, PM ;
DESCHEPPER, AM ;
BERRY, I ;
MANELFE, C ;
LEBRAS, F ;
MARSAULT, C ;
WICHMANN, W ;
VALAVANIS, A .
NEURORADIOLOGY, 1994, 36 (01) :27-30
[6]   Optimal Acquisition Delay for Dynamic Contrast-Enhanced MRI of Hypervascular Hepatocellular Carcinoma [J].
Goshima, Satoshi ;
Kanematsu, Masayuki ;
Kondo, Hiroshi ;
Shiratori, Yoshimune ;
Onozuka, Minoru ;
Moriyama, Noriyuki ;
Bae, Kyongtae T. .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2009, 192 (03) :686-692
[7]   Liver tumor characterization: Comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT - A multicenter trial [J].
Halavaara, J ;
Breuer, J ;
Ayuso, C ;
Balzer, T ;
Bellin, MF ;
Blomqvist, L ;
Carter, R ;
Grazioli, L ;
Hammerstingl, R ;
Huppertz, A ;
Jung, G ;
Krause, D ;
Laghi, A ;
Leen, E ;
Lupatelli, L ;
Marsili, L ;
Martin, J ;
Pretorius, ES ;
Reinhold, C ;
Stiskal, M ;
Stolpen, AH .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2006, 30 (03) :345-354
[8]   PHASE-I CLINICAL-EVALUATION OF GD-EOB-DTPA AS A HEPATOBILIARY MR CONTRAST AGENT - SAFETY, PHARMACOKINETICS, AND MR-IMAGING [J].
HAMM, B ;
STAKS, T ;
MUHLER, A ;
BOLLOW, M ;
TAUPITZ, M ;
FRENZEL, T ;
WOLF, KJ ;
WEINMANN, HJ ;
LANGE, L .
RADIOLOGY, 1995, 195 (03) :785-792
[9]   Diagnostic efficacy of gadoxetic acid (Primovist)-enhanced MRI and spiral CT for a therapeutic strategy:: comparison with intraoperative and histopathologic findings in focal liver lesions [J].
Hammerstingl, Renate ;
Huppertz, Alexander ;
Breuer, Josy ;
Balzer, Thomas ;
Blakeborough, Anthony ;
Carter, Rick ;
Fuste, Lluis Castells ;
Heinz-Peer, Gertraud ;
Judmaier, Werner ;
Laniado, Michael ;
Manfredi, Riccardo M. ;
Mathieu, Didier G. ;
Mueller, Dieter ;
Mortele, Koenraad ;
Reimer, Peter ;
Reiser, Maximilian F. ;
Robinson, Philip J. ;
Shamsi, Kohkan ;
Strotzer, Michael ;
Taupitz, Matthias ;
Tombach, Bernd ;
Valeri, Gianluca ;
van Beers, Bernhard E. ;
Vogl, Thomas J. .
EUROPEAN RADIOLOGY, 2008, 18 (03) :457-467
[10]   BASIC PHYSICS OF MR CONTRAST AGENTS AND MAXIMIZATION OF IMAGE-CONTRAST [J].
HENDRICK, RE ;
HAACKE, EM .
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING, 1993, 3 (01) :137-148