Silicon Photonic Label Free Biosensors with Coherent Readout

被引:1
作者
Leuermann, Jonas [1 ,2 ]
Fernandez-Gavela, Adrian [3 ]
Halir, Robert [1 ,2 ]
Ortega-Monux, A. [1 ,2 ]
Wanguemert-Perez, J. G. [1 ,2 ]
Lechuga, Laura M. [4 ,5 ]
Molina-Fernandez, I [1 ,2 ]
机构
[1] Univ Malaga, ETSI & Telecomunicac, Campus Teatinos, E-29071 Malaga, Spain
[2] P Tecnol Andalucia, Bionand Ctr Nanomed & Biotechnol, Malaga 29590, Spain
[3] Univ Oviedo, Dept Fis, C Federico Garcia Lorca, Oviedo 33007, Spain
[4] Catalan Inst Nanosci & Nanotechnol ICN2, CSIC, BIST, Nanobiosensors & Bioanalyt Applicat Grp, Campus UAB, Barcelona 08193, Spain
[5] BIST & CIBER BBN, Campus UAB, Barcelona 08193, Spain
来源
2020 22ND INTERNATIONAL CONFERENCE ON TRANSPARENT OPTICAL NETWORKS (ICTON 2020) | 2020年
关键词
label-free biosensors; integrated optics; silicon photonics;
D O I
10.1109/icton51198.2020.9203519
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
Silicon photonics enables sensitive and label-free optical biosensors for the detection of chemical and biological substances. Different sensing architectures have been used to improve the limit of detection and increase the dynamic range response. Here, we show experimental limit of detection at state-of-the-art level using silicon nitride integrated Mach-Zehnder interferometers with coherent read-out. These preliminary results are concordant with theoretical results, showing that the proposed approach enables the use of simple read-out equipment using low-cost laser sources.
引用
收藏
页数:4
相关论文
共 10 条
[1]  
Baets R, 2016, 2016 OPTICAL FIBER COMMUNICATIONS CONFERENCE AND EXHIBITION (OFC)
[2]   Last Advances in Silicon-Based Optical Biosensors [J].
Fernandez Gavela, Adrian ;
Grajales Garcia, Daniel ;
Ramirez, Jhonattan C. ;
Lechuga, Laura M. .
SENSORS, 2016, 16 (03)
[3]   Trends in photonic lab-on-chip interferometric biosensors for point-of-care diagnostics [J].
Gonzalez-Guerrero, A. B. ;
Maldonado, J. ;
Herranz, S. ;
Lechuga, L. M. .
ANALYTICAL METHODS, 2016, 8 (48) :8380-8394
[4]   Direct and Sensitive Phase Readout for Integrated Waveguide Sensors [J].
Halir, R. ;
Vivien, L. ;
Le Roux, X. ;
Xu, D. -X. ;
Cheben, P. .
IEEE PHOTONICS JOURNAL, 2013, 5 (04)
[5]   Label-Free Biosensor Arrays Based on Silicon Ring Resonators and High-Speed Optical Scanning Instrumentation [J].
Iqbal, Muzammil ;
Gleeson, Martin A. ;
Spaugh, Bradley ;
Tybor, Frank ;
Gunn, William G. ;
Hochberg, Michael ;
Baehr-Jones, Tom ;
Bailey, Ryan C. ;
Gunn, L. Cary .
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS, 2010, 16 (03) :654-661
[6]   Optimizing the Limit of Detection of Waveguide-Based Interferometric Biosensor Devices [J].
Leuermann, Jonas ;
Fernandez-Gavela, Adrian ;
Torres-Cubillo, Antonia ;
Postigo, Sergio ;
Sanchez-Postigo, Alejandro ;
Lechuga, Laura M. ;
Halir, Robert ;
Molina-Fernandez, Inigo .
SENSORS, 2019, 19 (17)
[7]   Study on the limit of detection in MZI-based biosensor systems [J].
Martens, Daan ;
Bienstman, Peter .
SCIENTIFIC REPORTS, 2019, 9 (1)
[8]   Fundamental limit of detection of photonic biosensors with coherent phase read-out [J].
Molina-Fernandez, Inigo ;
Leuermann, Jonas ;
Ortega-Monux, Alejandro ;
Gonzalo Wanguemert-Perez, J. ;
Halir, Robert .
OPTICS EXPRESS, 2019, 27 (09) :12616-12629
[9]   High-performance monolithically integrated 120° downconverter with relaxed hardware constraints [J].
Reyes-Iglesias, P. J. ;
Molina-Fernandez, I. ;
Moscoso-Martir, A. ;
Ortega-Monux, A. .
OPTICS EXPRESS, 2012, 20 (05) :5725-5741
[10]   Refractive Index Sensing Using a Three-Port Interferometer and Comparison with Ring Resonators [J].
Van Gulik, Ruben J.J. ;
De Boer, Bart M. ;
Harmsma, Peter J. .
IEEE Journal of Selected Topics in Quantum Electronics, 2017, 23 (02) :433-439