Synthesis of 4-Amino-Thiazole Analogs of Fmoc-Amino Acids and Thiazole Linked N-Orthogonally Protected Dipeptidomimetics

被引：10

作者：

Narendra, N. ^{[1
]}

Vishwanatha, T. M. ^{[1
]}

Sudarshan, N. S. ^{[1
]}

Sureshbabu, Vommina V. ^{[1
]}

机构：

[1] Bangalore Univ, Dept Studies Chem, Peptide Res Lab, Bangalore 560001, Karnataka, India

来源：

PROTEIN AND PEPTIDE LETTERS | 2009年 / 16卷 / 09期

关键词：

N-alpha-Fmoc-haloketones; N-Fmoc-4-amino-thiazolyl derivatives; heteroaryl alanine derivatives and dipeptide thiozoles; INHIBITION; DIPEPTIDE; AZIDE;

D O I：

10.2174/092986609789055403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked N-orthogonally protected dipeptidomimetics by the condensation of N-alpha-Fmoc alpha-halomethylketones with thiourea and Boc/Z-alpha-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4-amino thiazole moiety have also been synthesized following the similar protocol.

引用

页码：1029 / 1035

页数：7

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