Capsule switching among C:2b:P1.2,5 meningococcal epidemic strains after mass immunization campaign, Spain

被引：40

作者：

Alcalá, B ^{[1
]}

Arreaza, L ^{[1
]}

Salcedo, C ^{[1
]}

Uría, MJ ^{[1
]}

De la Fuente, L ^{[1
]}

Vázquez, JA ^{[1
]}

机构：

[1] Cent Nacl Microbiol, Inst Salud Carlos III, Reference Lab Meningococci, Majadahonda 28220, Madrid, Spain

来源：

EMERGING INFECTIOUS DISEASES | 2002年 / 8卷 / 12期

关键词：

D O I：

10.3201/eid0812.020081

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A mass immunization campaign for 18-month to 19-year-olds was undertaken in Spain in 1996-1997 because of an epidemic of serogroup C meningococcal disease associated with a C:2b-.P1.2,5 strain belonging to the A4 lineage. Surveillance for the "capsule-switching" phenomenon producing B:2b:P1.2,5 isolates was undertaken. Of 2,975 meningococci characterized, B:2b:P1.2,5 and B:2b:P1.2 antigenic combinations were found in 18 isolates; 15 meningococci were defined as serogroup B belonging to the A4 lineage.

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页码：1512 / 1514

页数：3

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