Successful Treatment with Rituximab in a Patient with Stiff-Person Syndrome Complicated by Dysthyroid Ophthalmopathy

被引：31

作者：

Katoh, Nagaaki ^{[1
]}

Matsuda, Masayuki ^{[1
]}

Ishii, Wataru ^{[1
]}

Morita, Hiroshi ^{[1
]}

Ikeda, Shu-ichi ^{[1
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Med Neurol & Rheumatol, Matsumoto, Nagano 390, Japan

来源：

INTERNAL MEDICINE | 2010年 / 49卷 / 03期

关键词：

stiff-person syndrome; dysthyroid ophthalmopathy; anti-glutamic acid decarboxylase (GAD) antibody; rituximab; ANTI-CD20; MONOCLONAL-ANTIBODY; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; GRAVES OPHTHALMOPATHY; THERAPY; LYMPHOMA;

D O I：

10.2169/internalmedicine.49.2821

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a patient with stiff-person syndrome and insulin-dependent diabetes mellitus with anti-glutamic acid decarboxylase (GAD) antibody, who suddenly complained of diplopia due to dysthyroid ophthalmopathy. Therapeutic efficacy of plasmapheresis and high-dose intravenous immunoglobulin was transient. After starting administration of rituximab, the patient showed obvious improvement of muscle spasms due to stiff-person syndrome and ophthalmoplegia following quick depletion of CD20-positive cells in peripheral blood. The anti-GAD and anti-thyroid antibodies decreased slowly. This drug might be a potent therapeutic option for refractory patients with stiff-person syndrome, particularly in those associated with dysthyroid ophthalmopathy.

引用

页码：237 / 241

页数：5

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