An Efficient one-pot enantio- and diastereoselective synthesis of heterocycles

被引：49

作者：

Trost, BM ^{[1
]}

Machacek, MR ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期

关键词：

alkylation; asymmetric synthesis; heterocycles; homogeneous catalysis; palladium; ruthenium;

D O I：

10.1002/anie.200290019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Five- and six-membered nitrogen and oxygen heterocycles are accessible from two acyclic precursors in a one-pot reaction that comprises a Ru-catalyzed eneyne addition followed by a Pd-catalyzed asymmetric allylic alkylation (see scheme). The stereochemistry of the products derives from the catalyst rather than from substrate control using chiral substrates.

引用

页码：4693 / 4697

页数：5

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