Imaging of regional metabolic activity by 18F-FDG/PET in rats with transient cerebral ischemia

被引：16
|
作者：
Fu, Ying-Kai [1 ,2 ]
Chang, Chia-Jung
Chen, Kuan-Yin
Hwang, Li-Chung
Wu, Kuo-Hung
Chang, Kang-Wei
Jan, Meei-Ling
Chen, Chia-Chieh
Chang, Chih-Hsien
机构：
[1] Inst Nucl Energy Res, Atom Energy Council, Tao Yuan 32546, Taiwan
[2] Chung Yuan Christian Univ, Dept Chem, Chungli 32023, Taiwan
来源：
APPLIED RADIATION AND ISOTOPES | 2009年 / 67卷 / 10期
关键词：
F-18-FDG; MicroPET; Rat ischemia model; TRAUMATIC BRAIN-INJURY; POSITRON-EMISSION-TOMOGRAPHY; IN-VIVO; OCCLUSION; RECOVERY; PET;
D O I：
10.1016/j.apradiso.2009.03.002
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that F-18-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with F-18-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents. (C) 2009 Elsevier Ltd. All rights reserved,
引用
收藏
页码：1743 / 1747
页数：5
相关论文
共 50 条
  • [1] 18F-FDG PET imaging of muscle activity in runners
    Tashiro, M
    Fujimoto, T
    Itoh, M
    Kubota, K
    Fujiwara, T
    Miyake, M
    Watanuki, S
    Horikawa, E
    Sasaki, H
    Ido, T
    JOURNAL OF NUCLEAR MEDICINE, 1999, 40 (01) : 70 - 76
  • [2] Detection of bladder metabolic artifacts in 18F-FDG PET imaging
    Roman-Jimenez, Geoffrey
    De Crevoisier, Renaud
    Leseur, Julie
    Devillers, Anne
    Ospina, Juan David
    Simon, Antoine
    Terve, Pierre
    Acosta, Oscar
    COMPUTERS IN BIOLOGY AND MEDICINE, 2016, 71 : 77 - 85
  • [3] Longitudinal studies of ischemic penumbra by using 18F-FDG PET and MRI techniques in permanent and transient focal cerebral ischemia in rats
    Sobrado, M.
    Delgado, M.
    Fernandez-Valle, E.
    Garcia-Garcia, L.
    Torres, M.
    Sanchez-Prieto, J.
    Vivancos, J.
    Manzanares, R.
    Moro, M. A.
    Pozo, M. A.
    Lizasoain, I.
    NEUROIMAGE, 2011, 57 (01) : 45 - 54
  • [4] Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG
    Balsara, Rashna D.
    Chapman, Sarah E.
    Sander, Ian M.
    Donahue, Deborah L.
    Liepert, Lucas
    Castellino, Francis J.
    Leevy, W. Matthew
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2014, (94):
  • [5] 18F-FDG PET/CT Imaging In Oncology
    Almuhaideb, Ahmad
    Papathanasiou, Nikolaos
    Bomanji, Jamshed
    ANNALS OF SAUDI MEDICINE, 2011, 31 (01) : 3 - 13
  • [6] Biological characteristics of 18F-FDG PET/CT imaging of cerebral alveolar echinococcosis
    Yibulayin, Amina
    Li, Xiao-Hong
    Qin, Yong-De
    Jia, Xiao-Yan
    Zhang, Qi-Zhou
    Li, Yu-Bin
    MEDICINE, 2018, 97 (39)
  • [7] Brain 18F-FDG PET Imaging in the Differential Diagnosis of Parkinsonism
    Akdemir, Umit Ozgur
    Tokcaer, Ayse Bora
    Karakus, Asl
    Kapucu, Lutfiye Ozlem
    CLINICAL NUCLEAR MEDICINE, 2014, 39 (03) : E220 - E226
  • [8] Role of 18F-FDG PET/CT Imaging in Intrahepatic Cholangiocarcinoma
    Jiang, Lei
    Tan, Hui
    Panje, Cedric M.
    Yu, Haojun
    Xiu, Yan
    Shi, Hongcheng
    CLINICAL NUCLEAR MEDICINE, 2016, 41 (01) : 1 - 7
  • [9] Metabolic Imaging of Deep Brain Stimulation in Anorexia Nervosa A 18F-FDG PET/CT Study
    Zhang, Hui-Wei
    Li, Dian-You
    Zhao, Jun
    Guan, Yi-Hui
    Sun, Bo-Min
    Zuo, Chuan-Tao
    CLINICAL NUCLEAR MEDICINE, 2013, 38 (12) : 943 - 948
  • [10] High metabolic characteristics of uterine fibroids in 18F-FDG PET/CT imaging and the underlying mechanisms
    Ma, Yan
    Shao, Xiaonan
    Shao, Xiaoliang
    Wang, Xiaosong
    Wang, Yuetao
    NUCLEAR MEDICINE COMMUNICATIONS, 2016, 37 (11) : 1206 - 1211
12345