Clinical comparison of selective and non-selective alpha(1)A-adrenoreceptor antagonists in benign prostatic hyperplasia: studies on tamsulosin in a fixed dose and terazosin in increasing doses

被引:107
作者
Lee, E [1 ]
Lee, C [1 ]
机构
[1] SEOUL NATL UNIV, COLL MED, DEPT UROL, SEOUL, SOUTH KOREA
来源
BRITISH JOURNAL OF UROLOGY | 1997年 / 80卷 / 04期
关键词
benign prostatic hyperplasia; selective and non-selective alpha(1)A-adrenoreceptor antagonist; tamsulosin; terazosin; lower urinary tract symptoms;
D O I
10.1046/j.1464-410X.1997.00411.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Objective To compare the efficacy and safety of a fixed dose (0.2 mg) of tamsulosin, a selective alpha(1)A-adrenoreceptor antagonist, with an increasing dose (1-5 mg) of terazosin, a non-selective antagonist, in the treatment of urinary outflow obstruction associated with benign prostatic hyperplasia (BPH) in Korean patients. Patients and methods The study comprised a single-blind and randomized design with tamsulosin or terazosin taken once daily for 8 weeks. A total of 98 patients was enrolled, with 72 patients included in the analyses after 4 and 8 weeks. The primary variables assessed were changes in the maximum urinary flow rate (Q(max)) and the total international Prostate Symptom Score (IPSS), with the post-void residual urine volume, 'obstructive' and 'irritative' questions in the IPSS, and the investigators' global assessment of efficacy also determined. The number of patients with a clinically significant response to treatment with tamsulosin or terazosin was determined and defined as those with >20% improvement from the baseline Q(max),, or >20% decrease in total IPSS. Adverse reactions possibly or probably related to study medication were recorded throughout the treatment period. Results Both tamsulosin and terazosin produced similar significant improvements in subjective and objective symptoms of urinary outflow obstruction (P>0.05). Systolic and diastolic (standing) blood pressures decreased significantly in patients treated with terazosin (P<0.05). The adverse reactions, most frequently dry mouth and dizziness which were usually mild and transient, were significantly higher in patients on terazosin (18 patients, versus one on tamsulosin, P<0.001). The changes led to discontinuation of therapy in two patients on terazosin. Conclusion Tamsulosin was as effective as terazosin in treating urinary outflow obstruction associated with BPH, but had a markedly better safety profile.
引用
收藏
页码:606 / 611
页数:6
相关论文
共 28 条
  • [1] TAMSULOSIN, A SELECTIVE ALPHA(1C)-ADRENOCEPTOR ANTAGONIST - A RANDOMIZED, CONTROLLED TRIAL IN PATIENTS WITH BENIGN PROSTATIC OBSTRUCTION (SYMPTOMATIC BPH)
    ABRAMS, P
    SCHULMAN, CC
    VAAGE, S
    ABEL, P
    BAXBY, K
    BOEMINGHAUS, F
    DELAERE, KPJ
    DENIS, L
    DIJKMAN, GA
    HASSELLUND, S
    HOHENFELLNER, R
    JANKNEGT, RA
    KAPPER, BJ
    KARTHAUS, HFM
    KHOE, GSS
    KIL, PJM
    KROMANNANDERSEN, B
    LELIEFELD, HHJ
    LOCK, TMTW
    MOHR, M
    MOMMSEN, S
    OGREID, P
    OTTO, RW
    PLASMAN, JWMH
    PULL, HC
    RYTTOV, N
    TOLLEY, DA
    VENEMA, PL
    WYNDAELE, JJ
    YPMA, AFGVM
    [J]. BRITISH JOURNAL OF UROLOGY, 1995, 76 (03): : 325 - 336
  • [2] Brawer M K, 1993, Arch Fam Med, V2, P929, DOI 10.1001/archfami.2.9.929
  • [3] A 3 MONTH DOUBLE-BLIND-STUDY OF DOXAZOSIN AS TREATMENT FOR BENIGN PROSTATIC BLADDER OUTLET OBSTRUCTION
    CHAPPLE, CR
    CARTER, P
    CHRISTMAS, TJ
    KIRBY, RS
    BRYAN, J
    MILROY, EJG
    ABRAMS, P
    [J]. BRITISH JOURNAL OF UROLOGY, 1994, 74 (01): : 50 - 56
  • [4] Chapple CR, 1996, EUR UROL, V29, P129
  • [5] USE OF RECOMBINANT ALPHA(1)-ADRENOCEPTORS TO CHARACTERIZE SUBTYPE SELECTIVITY OF DRUGS FOR THE TREATMENT OF PROSTATIC HYPERTROPHY
    FOGLAR, R
    SHIBATA, K
    HORIE, K
    HIRASAWA, A
    TSUJIMOTO, G
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1995, 288 (02): : 201 - 207
  • [6] ALPHA-1-ADRENOCEPTOR CLASSIFICATION - SHARPENING OCCAM RAZOR
    FORD, APDW
    WILLIAMS, TJ
    BLUE, DR
    CLARKE, DE
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1994, 15 (06) : 167 - 170
  • [7] GARCIASAINZ JA, 1995, EUR J PHARM-MOLEC PH, V289, P1
  • [8] HIGH PREVALENCE OF BENIGN PROSTATIC HYPERTROPHY IN THE COMMUNITY
    GARRAWAY, WM
    COLLINS, GN
    LEE, RJ
    [J]. LANCET, 1991, 338 (8765) : 469 - 471
  • [9] PHARMACOLOGICAL EVIDENCE OF DISTINCT ALPHA(1)-ADRENOCEPTOR SUBTYPES MEDIATING THE CONTRACTION OF HUMAN PROSTATIC URETHRA AND PERIPHERAL ARTERY
    HATANO, A
    TAKAHASHI, H
    TAMAKI, M
    KOMEYAMA, T
    KOIZUMI, T
    TAKEDA, M
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1994, 113 (03) : 723 - 728
  • [10] HIEBLE JP, 1985, EUR J PHARMACOL, V107, P111