The choroid plexus as a site of damage in hemorrhagic and ischemic stroke and its role in responding to injury

被引：35

作者：

Xiang, Jianming ^{[1
]}

Routhe, Lisa J. ^{[2
]}

Wilkinson, D. Andrew ^{[1
]}

Hua, Ya ^{[1
]}

Moos, Torben ^{[2
]}

Xi, Guohua ^{[1
]}

Keep, Richard F. ^{[1
,3
]}

机构：

[1] Univ Michigan, Dept Neurosurg, R5018 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA

[2] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark

[3] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

来源：

FLUIDS AND BARRIERS OF THE CNS | 2017年 / 14卷

基金：

美国国家卫生研究院;

关键词：

Intraventricular hemorrhage; Subarachnoid hemorrhage; Intracerebral hemorrhage; Cerebral ischemia; Choroid plexus; Cerebrospinal fluid; Blood-brain barrier; ENDOTHELIAL GROWTH-FACTOR; FOCAL CEREBRAL-ISCHEMIA; NEONATAL POSTHEMORRHAGIC HYDROCEPHALUS; TRANSIENT FOREBRAIN ISCHEMIA; CEREBROSPINAL-FLUID BARRIER; ARTERY TERRITORY INFARCTION; SPONTANEOUS INTRACEREBRAL HEMORRHAGE; ANEURYSMAL SUBARACHNOID HEMORRHAGE; TISSUE-PLASMINOGEN ACTIVATOR; NITRIC-OXIDE PRODUCTION;

D O I：

10.1186/s12987-017-0056-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While the impact of hemorrhagic and ischemic strokes on the blood-brain barrier has been extensively studied, the impact of these types of stroke on the choroid plexus, site of the blood-CSF barrier, has received much less attention. The purpose of this review is to examine evidence of choroid plexus injury in clinical and preclinical studies of intraventricular hemorrhage, subarachnoid hemorrhage, intracerebral hemorrhage and ischemic stroke. It then discusses evidence that the choroid plexuses are important in the response to brain injury, with potential roles in limiting damage. The overall aim of the review is to highlight deficiencies in our knowledge on the impact of hemorrhagic and ischemic strokes on the choroid plexus, particularly with reference to intraventricular hemorrhage, and to suggest that a greater understanding of the response of the choroid plexus to stroke may open new avenues for brain protection.

引用

页数：13

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