A new electrochemical DNA biosensor based on modified carbon paste electrode using graphene quantum dots and ionic liquid for determination of topotecan

被引：121
作者：
Mahmoudi-Moghaddam, Hadi [1 ,2 ]
Tajik, Somayeh [3 ]
Beitollahi, Hadi [4 ]
机构：
[1] Kerman Univ Med Sci, Environm Hlth Engn Res Ctr, Kerman, Iran
[2] Kerman Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth, Kerman, Iran
[3] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran
[4] Grad Univ Adv Technol, Inst Sci & High Technol & Environm Sci, Environm Dept, Kerman, Iran
来源：
MICROCHEMICAL JOURNAL | 2019年 / 150卷
关键词：
Topotecan; Ds-DNA; Graphene quantum dots; Ionic liquid; Carbon paste electrode; VOLTAMMETRIC DETERMINATION; SENSITIVE DETERMINATION; DRUG; NANOCOMPOSITE; SENSOR; CHROMATOGRAPHY; MECHANISM; CONSTRUCT; TYROSINE; PLASMA;
D O I：
10.1016/j.microc.2019.104085
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
To study topotecan-DNA interaction and topotecan determination with a modified carbon paste electrode (CPE), a new electrochemical biosensor is introduced. The biosensor was prepared through modification of a CPE with ionic liquid (IL), graphene quantum dots and double stranded DNA (ds-DNA). Compared to reported conventional DNA sensors, the modified electrode displayed high sensitivity and selectivity, respectable reproducibility and satisfactory stability. Moreover, the differential-pulse voltammetric (DPV) peak current was linear to topotecan concentration in the range of 0.35-100.0 mu M, with a detection limit (LOD) of 0.1 mu M. Applying the proposed method to determine topotecan in blood serum and urine, the use of this screening method for analyzing real sample was studied. In general, the results indicated that this DNA biosensor could be used for the fast, simple, sensitive, and cost effective determination of topotecan in urine and serum samples.
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页数：9
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共 46 条
[1]   Spectroscopic studies of the effects of anticancer drug mitoxantrone interaction with calf-thymus DNA [J].
Agarwal, Shweta ;
Jangir, Deepak Kumar ;
Mehrotra, Ranjana .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 2013, 120 :177-182
[2]   Capillary electrophoresis for studying drug-DNA interactions [J].
Araya, Fitsumbirhan ;
Huchet, Guillaume ;
McGroarty, Lain ;
Skellern, Graham G. ;
Waigh, Roger D. .
METHODS, 2007, 42 (02) :141-149
[3]   An ultrasensitive hollow-silica-based biosensor for pathogenic Escherichia coli DNA detection [J].
Ariffin, Eda Yuhana ;
Lee, Yook Heng ;
Futra, Dedi ;
Tan, Ling Ling ;
Abd Karim, Nurul Huda ;
Ibrahim, Nik Nuraznida Nik ;
Ahmad, Asmat .
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 410 (09) :2363-2375
[4]   Determination of plasma topotecan and its metabolite N-desmethyl topotecan as both lactone and total form by reversed-phase liquid chromatography with fluorescence detection [J].
Bai, F ;
Kirstein, MN ;
Hanna, SK ;
Iacono, LC ;
Johnston, B ;
Stewart, CF .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 784 (02) :225-232
[5]   Voltammetric determination of dopamine in the presence of tyrosine using graphite screen-printed electrode modified with graphene quantum dots [J].
Beitollahi, Hadi ;
Dourandish, Zahra ;
Ganjali, Mohammad Reza ;
Shakeri, Shahryar .
IONICS, 2018, 24 (12) :4023-4031
[6]   Simultaneous voltammetric determination of droxidopa, acetaminophen, and tyrosine on hematoxylin and graphene oxide/ZnO nanocomposite-modified glassy carbon electrode [J].
Beitollahi, Hadi ;
Salimi, Hadiseh ;
Ganjali, Mohammad Reza .
IONICS, 2018, 24 (05) :1487-1495
[7]   Application of a nanostructured sensor based on graphene- and ethyl 2-(4-ferrocenyl[1,2,3]triazol-1-yl)acetate-modified carbon paste electrode for determination of methyldopa in the presence of phenylephrine and guaifenesin [J].
Beitollahi, Hadi ;
Movlaee, Kaveh ;
Ganjali, Mohammad Reza ;
Norouzi, Parviz ;
Hosseinzadeh, Rahman .
APPLIED ORGANOMETALLIC CHEMISTRY, 2018, 32 (04)
[8]   Application of antibody nanogold ionic liquid carbon paste electrode for sensitive electrochemical immunoassay of thyroid-stimulating hormone [J].
Beitollahi, Hadi ;
Ivari, Susan Ghofrani ;
Torkzadeh-Mahani, Masoud .
BIOSENSORS & BIOELECTRONICS, 2018, 110 :97-102
[9]   A Sensitive Electrochemical DNA Biosensor for Anticancer Drug Topotecan Based on Graphene Carbon Paste Electrode [J].
Beitollahi, Hadi ;
Dehghannoudeh, Gholamreza ;
Moghaddam, Hadi Mahmoudi ;
Forootanfar, Hamid .
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 2017, 164 (12) :II812-II817
[10]   The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions [J].
Bergamo, Alberta ;
Dyson, Paul J. ;
Sava, Gianni .
COORDINATION CHEMISTRY REVIEWS, 2018, 360 :17-33
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